Parkinson's Disease Dementia Clinical Trial
Official title:
A Six-month Observational Study to Investigate Prevalence of Neuropsychiatric Symptom in Korean Patients With Parkinson's Disease Dementia
- Dementia correlates to decreased cognitive function, and Behavioral and Psychological
Symptoms of Dementia (Neuropsychiatric symptom, BPSD) as well.
- Neuropsychiatric symptom attributes important role for mortality, mortality, and cause
to enter nursing home.
- Study on neuropsychiatric symptom in patients with Parkinson's disease has not been
thorough yet, and there even has not been any study done on this in Korea yet.
- The investigators will study prevalence of neuropsychiatric symptom in PDD patients and
burden of caregiver.
- It is well recognized that the importance of non-motor symptoms of Parkinson's disease
during its progression and many patients are suffering from this. The deterioration of
cognitive function is especially known as a crucial prognostic factor. According to
recently released cohort study, majority of patients go through dementia in advanced
Parkinson's disease.
- Dementia correlates to decreased cognitive function, and Behavioral and Psychological
Symptoms of Dementia (Neuropsychiatric symptom, BPSD) as well. Neuropsychiatric symptom
composed of abnormal behavior and psychological symptoms: abnormal behaviors include
combativeness, wandering, agitation, akathisia, inappropriate sexual behavior,
following caregiver, shouting, cursing, insomnia and binge eating while psychological
symptoms include anxiety, depression, hallucination, and illusion. Neuropsychiatric
symptom is evaluated depending on information given by caregivers, and symptoms are
likely to be temporary or changing constantly. Two thirds of patients is found to have
neuropsychiatric symptom when they are diagnosed as dementia, 65 % in nursing home and
70~90% in advanced dementia states. Neuropsychiatric symptom attributes important role
for mortality, mortality, and cause to enter nursing home.
- Besides, neuropsychiatric symptom also plays important part as care-giver burden. It
gives heavier burden on caregiver rather than on patients, and increases depression and
anxiety of caregivers. Specific correlation with patient's neuropsychiatric symptom to
burden of caregiver is known as agitation, depression, aggression, repetitive behavior,
anxiety, and disinhibition. There are, however, various results related to race,
region, subjects, and investigator.
- Study on neuropsychiatric symptom in patients with Parkinson's disease dementia has not
been thorough yet, and there even has not been any study done on this in Korea yet.
- The investigators will study prevalence of neuropsychiatric symptom in PDD patients and
burden of caregiver.
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Observational Model: Cohort, Time Perspective: Prospective
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