Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease

Parkinson Disease Clinical Trial

— HPGAIT  

Official title:

Characterization of Dynamic Stability in Normal Pressure Hydrocephalus and Parkinson's Disease

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05998473
• Other study ID #: 2023-A01762-43
• Status: Active, not recruiting
• Start date: June 1, 2023
• Est. completion date: December 31, 2023

Study information

• Verified date: August 2023
• Source: Henri Mondor University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study aims to characterize dynamic stability disorders in two conditions mainly affecting the elderly and with similar walking deficits: hydrocephalus at normal pressure and Parkinson's disease, to provide the most relevant monitoring criteria in usual care.

Description:

Walking disorders in normal pressure hydrocephalus are manifested by slowing and ataxic gait, similar to disorders in Parkinson's disease. No studies in the literature have focused on advanced measures of dynamic stability in hydrocephalus at normal pressure, compared to Parkinson's disease, on large samples. The Laboratory of Analysis and Restoration of Movement, located in a Neurorehabilitation Department, provides quantitative data on gait and in particular dynamic stability as part of additional assessments to help patients follow up. Since 2010, people with normal pressure hydrocephalus or Parkinson's disease regularly benefit from these assessments. Retrospective analysis of all these data would help to better characterize motor disorders in hydrocephalus at normal pressure, by discriminating them from those associated with Parkinson's disease. It would lead to the definition of relevant indices to be used for patient follow-up.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 150
• Est. completion date: December 31, 2023
• Est. primary completion date: September 30, 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria:

• Age >18 years

• Patient who performed a walking test in the Laboratory Analysis and Restoration of Movement

• Diagnosis of normal pressure hydrocephalus or Parkinson's disease

Exclusion Criteria:

• Levodopa drugs administrated during a delay of 12 hours before walking test

• Presence of an other neurologic disease or of any disease associated with motor disorders in lower limb.

Related Conditions & MeSH terms

• Diagnoses Disease
• Gait Ataxia
• Hydrocephalus
• Hydrocephalus, Normal Pressure
• Mobility Limitation
• Movement Disorders
• Parkinson Disease
• Walking, Difficulty

Intervention

Diagnostic Test:
• Dynamic stability measurement
The subject is asked to walk 8 meters 3 times: at free speed, at fast speed, and with large steps.

Locations

Country	Name	City	State
France	Laboratoire Analyse et Restauration du Mouvement	Créteil

Sponsors (1)

Lead Sponsor	Collaborator
Henri Mondor University Hospital

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Coefficient of variation in step length	Coefficient of variation in step length during 8-meter comfortable walking test	30 seconds