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Curative Effect and Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation on Non-motor Symptoms of PD

Parkinson Disease Clinical Trial

Official title:
Study on the Efficacy and Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation in the Treatment of Non-motor Symptoms of Parkinson's Disease

Clinical Trial Summary

This study is a double-blind comparative study examining the curative effect and mechanism of the transcutaneous auricular vagus nerve stimulation treatment on non-motor symptoms of Parkinson's disease patients. The investigators hypothesize that treatment using transcutaneous auricular vagus nerve stimulation will improve the non-motor symptoms, such as improving sleep, and improve cortical activity simultaneously in Parkinson's disease patients.

Clinical Trial Description

Patients in the Experimental group underwent fourteen consecutive daily sessions of transcutaneous auricular vagus nerve stimulation (taVNS, twice daily, 30 minutes each time), whereas patients in the sham stimulation group underwent fourteen consecutive daily sessions of sham taVNS. Assessments of motor and non-motor symptoms, excitability of cortex motor (using repetitive transcranial magnetic stimulation), cortical activity (using Functional near-infrared spectroscopy) and blood indicators were performed three times: at baseline, one day post intervention, fourteen days post intervention. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05806736
Study type Interventional
Source The First Affiliated Hospital with Nanjing Medical University
Contact Kezhong Zhang
Phone 13770840575
Email kezhong_zhang1969@126.com
Status Recruiting
Phase N/A
Start date September 1, 2022
Completion date July 2023
View Details
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