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The Effect of Intranasal Insulin on Motor and Non-motor Symptoms in Parkinson's Disease Patients

Parkinson Disease Clinical Trial

Official title:
Evaluating the Effect of Intranasal Insulin Administration on Motor and Non-motor Symptoms in Parkinson's Disease Patients; a Randomized Double-blinded Placebo-controlled Clinical Trial

Clinical Trial Summary

This study will evaluate the effect of intranasal insulin on motor and non-motor symptoms of patients with Parkinson's disease over a 12-week period.

Clinical Trial Description

This study is a single-center, parallel and double-blind study. Patients with Parkinson's disease referred to Movement Clinic of Shohada-e-Tajrish Hospital will randomly receive intranasal placebo or insulin, every day, twice a day for 12 weeks. Motor and non-motor symptoms will be evaluated in four time points; baseline, 4, 8 and 12 weeks after treatments. Primary outcome is motor symptoms (MDS-UPDRS; part III, IV), and secondary outcomes are motor (gait balance) and non-motor (MDS-UPDRS part I, II, cognition, depression, anxiety and fatigue) symptoms. Patients, researchers (physicians, outcome assessors) and data analysts are blinded. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04687878
Study type Interventional
Source Shahid Beheshti University of Medical Sciences
Contact
Status Completed
Phase Phase 2
Start date January 1, 2020
Completion date September 20, 2023
View Details
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