Parkinson Disease Clinical Trial
Official title:
Study on the Effects of Single Nucleotide Polymorphisms in Aquaporin-4 (AQP4) Gene on the Clinical Phenotype in Patients With Idiopathic and Familial Parkinson's Disease.
The purpose of this study is to understand the relationship between problems in sleep, genetic variations in the Aquaporin-4 gene (AQP4), and the development of Parkinson's Disease.
Status | Recruiting |
Enrollment | 800 |
Est. completion date | September 1, 2024 |
Est. primary completion date | September 1, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 85 Years |
Eligibility | Inclusion Criteria: - 18-85 years of age - Able to give informed consent - Able to perform online neuropsychological examinations - Diagnosis of PD according to Brain Bank Criteria - No presence or personal or family history of other neurological or psychiatric disorders Exclusion Criteria: - Presence of other neurological disorders and known intracranial co-morbidities such as stroke, haemorrhage, space-occupying lesions - Inability to perform online neuropsychological assessment - Inability to have access to informatics technology to perform the online assessment tests - Inability to travel for the assessments - Native language different from English |
Country | Name | City | State |
---|---|---|---|
United Kingdom | East Kent University Hospitals NHS Foundation Trust | Ashford | |
United Kingdom | University of Exeter | Exeter | |
United Kingdom | Prince Phillip Hospital | Llanelli | |
United Kingdom | Lewisham and Greenwich NHS Foundation Trust | London |
Lead Sponsor | Collaborator |
---|---|
University of Exeter |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Association between genetic variations in the AQP4 gene and worse motor symptoms in PD patients | The presence of genetic variations in the AQP4 gene, measured with single nucleotide polymorphisms will be correlated, in idiopathic and familial PD patients, with higher (worse) scores on the Hoehn & Yahr scales | Up to 36 months | |
Primary | Association between genetic variations in the AQP4 gene and worse cognitive symptoms in PD patients | The presence of genetic variations in the AQP4 gene, measured with single nucleotide polymorphisms will be correlated, in idiopathic and familial PD patients, with lower (worse) scores on Montreal Cognitive Assessment (MoCA) scale | Up to 36 months | |
Primary | Association between genetic variations in the AQP4 gene and worse sleep symptoms in PD patients | The presence of genetic variations in the AQP4 gene, measured with single nucleotide polymorphisms will be correlated, in idiopathic and familial PD patients, with worse sleep performances as assessed with sleep scales and Actigraph | Up to 36 months | |
Primary | Association between genetic variations in the AQP4 gene and worse non-motor symptoms in PD patients | The presence of genetic variations in the AQP4 gene, measured with single nucleotide polymorphisms will be correlated, in idiopathic and familial PD patients, with higher (worse) scores on scales for non-motor symptoms. | Up to 36 months | |
Secondary | Association between genetic variations in the AQP4 gene and altered levels of glymphatic system markers in PD patients | The presence of genetic variations in the AQP4 gene, measured with single nucleotide polymorphisms will be correlated, in idiopathic and familial PD patients, with increased levels of blood concentration of LRP-1, ABCB1 and AQP4 | Up to completion of study | |
Secondary | Association between genetic variations in the AQP4 gene and altered levels of astrocytic | The presence of genetic variations in the AQP4 gene, measured with single nucleotide polymorphisms will be correlated, in idiopathic and familial PD patients, with increased levels of blood concentration of S100ß | Up to completion of study | |
Secondary | Association between genetic variations in the AQP4 gene and altered levels of protein aggregation markers in PD patients | The presence of genetic variations in the AQP4 gene, measured with single nucleotide polymorphisms will be correlated, in idiopathic and familial PD patients, with increased levels of blood concentration of a-synuclein | Up to completion of study |
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