Parkinson Disease Clinical Trial
— eyebrainparkOfficial title:
Study of Eye Movements (EYE) as Early Markers of Brain Dysfunction (BRAIN) in Parkinson's Disease (PARK)
Identify the neural bases of eye movements during visual tasks and their dysfunction at early stages of Parkinson disease (de novo).
Status | Not yet recruiting |
Enrollment | 80 |
Est. completion date | January 2022 |
Est. primary completion date | December 2021 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility | Inclusion Criteria for all: - Visual acuity normal or corrected to normal - Affiliation to a social security scheme (copy of the vital card in support) - Signed informed consent - Medical examination according to the participation in the MRI examination - MMSE score> 23/30 For Parkinson patient: - Diagnosis of Parkinson's disease - Presence of asymmetric bradykinesia and rest tremor and / or stiffness - Hoehn & Yahr Stadium I-II / V Exclusion Criteria for all: - Unprotected Majors unable to express their consent - Protected Major (Persons mentioned in Articles L1121-5,6 and 8 of the public health code) - Significant hearing or motor impairment - Past or present neuropsychiatric pathology (except benign epilepsy) - Taking narcotics and / or drugs for neurocognitive purposes - Existence of a severe condition in general (cardiac, respiratory, hematological, renal, hepatic, cancerous) - Any other neurodegenerative pathology or treatment that may affect the oculomotor control For Parkinson patient: - Treatment for Parkinson's disease (except the inhibitors of monoaminoxidase B or MAO-B, such as selegiline and rasagiline). |
Country | Name | City | State |
---|---|---|---|
France | CHU Grenoble-Alpes | Grenoble |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Grenoble | Laboratoire de Psychologie et NeuroCognition |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | MRI images | Functional and anatomical brain volumes | 1 hour | |
Secondary | Eye latency | latency (milliseconds) of ocular saccades | 1 hour | |
Secondary | eye amplitude | amplitude (degree) of ocular saccades | 1 hour |
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