Parkinson Disease Clinical Trial
— OxQUIPOfficial title:
Oxford Study of Quantification in Parkinsonism Study - OXQUIP
The OxQUIP (Oxford QUantification In Parkinsonism) study is recruiting patients with Parkinson's Disease and Progressive Supranuclear Palsy. Currently available treatments for these diseases are symptomatic only, and do not have any preventive or disease-slowing effect. As new drugs are developed, there is a need to be able to evaluate them quickly, so that precious time and resources can be devoted to those showing most promise. This study follows participants intensively over an initially 3 year period, with the aim of identifying measures that can detect disease progression over much shorter time periods than is possible at present. During the study participants are asked to perform simple tasks while the investigators measure movements of the eyes, hands and body. The investigators also do some tasks on a tablet computer that measure cognitive performance.
Status | Recruiting |
Enrollment | 300 |
Est. completion date | December 2023 |
Est. primary completion date | August 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 50 Years and older |
Eligibility | Inclusion Criteria: - The participant may enter the study as a patient participant if ALL of the following apply: - Participant is willing and able to give informed consent for participation in the study - Fluent in English - Male or Female, aged 50 years or above - Patient diagnosed with PD or PSP by a specialist movement disorders neurologist, or age matched healthy control (often but not always the spouse of a patient) - No evidence of significant cognitive impairment - Normal or corrected-to-normal vision in both eyes The participant may enter the study as a healthy control if ALL of the following apply: - Participant is willing and able to give informed consent for participation in the study - Fluent in English - Male or Female, aged 50 years or above - No history of neurological disease - No evidence of significant cognitive impairment - Normal or corrected-to-normal vision in both eyes Exclusion Criteria: The participant may not enter the study if ANY of the following apply: - Patient is unwilling or unable to give informed consent. - Significant neurological co-morbidity that may obfuscate interpretation of neurophysiological or cognitive test results, for example major stroke. - Severe mental impairment due to dementia or psychosis - Medical or psychiatric illness that would interfere with completing initial or any of the follow up assessments - History of photosensitive epilepsy |
Country | Name | City | State |
---|---|---|---|
United Kingdom | John Radcliffe Hospital | Headington | Please Select |
Lead Sponsor | Collaborator |
---|---|
University of Oxford | UCB Belgium |
United Kingdom,
De Vos M, Prince J, Buchanan T, FitzGerald JJ, Antoniades CA. Discriminating progressive supranuclear palsy from Parkinson's disease using wearable technology and machine learning. Gait Posture. 2020 Mar;77:257-263. doi: 10.1016/j.gaitpost.2020.02.007. Ep — View Citation
Lu Z, Buchanan T, Kennard C, FitzGerald JJ, Antoniades CA. The effect of levodopa on saccades - Oxford Quantification in Parkinsonism study. Parkinsonism Relat Disord. 2019 Nov;68:49-56. doi: 10.1016/j.parkreldis.2019.09.029. Epub 2019 Sep 27. — View Citation
Patel S, Fitzgerald JJ, Antoniades CA. Oculomotor effects of medical and surgical treatments of Parkinson's disease. Prog Brain Res. 2019;249:297-305. doi: 10.1016/bs.pbr.2019.04.020. Epub 2019 May 20. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Saccadic eye movements | Automated measurements of rapid conjugate eye movements using a device called a saccadometer. | 3 months, 6 months, 12 months, 18 months, 21 months, 24 months, 27 months and 30 months. | |
Primary | Hand tapping | Measurement of rate of hand tapping movements made by participant on an electronic pad. | 3 months, 6 months, 12 months, 18 months, 21 months, 24 months, 27 months and 30 months | |
Primary | Reaction times using a button box | Measurement of response time when participant is required to press a button when a light is illuminated. | 3 months, 6 months, 12 months, 18 months, 21 months, 24 months, 27 months and 30 months | |
Primary | Gait measurement | Characterisation of gait abnormalities using a body-worn array of inertial measurement units | 3 months, 6 months, 12 months, 18 months, 21 months, 24 months, 27 months and 30 months | |
Primary | Mini Mental State Examination (MMSE) cognitive tablet | This is a standard clinical test for cognitive impairment | 3 months, 6 months, 12 months, 18 months, 21 months, 24 months, 27 months and 30 months | |
Primary | Montreal Cognitive Assessment (MOCA) | This is a standard clinical test for cognitive impairment | 3 months, 6 months, 12 months, 18 months, 21 months, 24 months, 27 months and 30 months | |
Primary | Verbal fluency test measurement | Measures a participant's ability to produce a list of words according to set criteria e.g. words starting with a specific letter of the alphabet. | 3 months, 6 months, 12 months, 18 months, 21 months, 24 months, 27 months and 30 months | |
Primary | Executive function testing (Oxford Cognitive Screen) | This is an electronic tablet-based battery of tasks intended to screen for deficits in executive function. | 3 months, 6 months, 12 months, 18 months, 21 months, 24 months, 27 months and 30 months |
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