Parkinson Disease Clinical Trial
Official title:
Intensive Running Exercise Improves Parkinson's Motor and Non-motor Symptoms
High quality clinical trial and meta-analysis have demonstrated short term, and to a lesser
extent, long term benefits in various outcome measures. To achieve positive effects,
supervised progressive strength and aerobic endurance training program of 12 weeks was
required. Extended progressive strength training improved muscle strength for up to 24
months. While aerobic endurance training would increase walking capacity up to 16 months. 1
There are data suggesting a threshold of intensity of exercise to be reached for the positive
effect. This overall body of evidence suggests that regular vigorous exercise should be
accorded a central place in the treatment of Parkinson's disease.
However, there was no evidence about regular intensive exercise of running in Parkinson's
disease. And most of the studies were not randomized with a control group.
In this study, the investigators are to investigate the effect of regular vigorous aerobic
exercise training of running on motor and non-motor symptoms, and quality-of-life of people
with Parkinson's disease.
There is growing volume of evidences support the positive effect of exercise and physical
therapy to Parkinson's disease. Various exercise types have shown different positive effects.
Gait training for 4 weeks showed a moderate improvement in balancing while balance training
of 8 to 26 weeks decreased fall rate. Cued exercise would mildly increase the speed of the
gait. Complementary exercises, such as Tai Chi and dancing, have shown improvement in
balancing of the patients.
One of the main complaints of Parkinson's disease is rigidity. It is because of the
musculoskeletal impairments which compromise the flexibility and stability of both axial
structure (spine) and the extremities. Truncal stiffness and rigidity results in a stooped
posture, which further undermines one's balance and agility. Flexibility training
(stretching) is shown to be beneficial to all stages of patients with Parkinson's disease, in
terms of improved both range of movement in joints and spinal stability. It is recommended
that regular stretching should be the first step in one's exercise program to combat the
muscle rigidity. High quality clinical trial and meta-analysis have demonstrated short term,
and to a lesser extent, long term benefits in various outcome measures. To achieve positive
effects, supervised progressive strength and aerobic endurance training program of 12 weeks
was required. Extended progressive strength training improved muscle strength for up to 24
months. While aerobic endurance training would increase walking capacity up to 16 months.
There are data suggested a threshold of intensity of exercise to be reached for the positive
effect. This overall body of evidence suggests that regular vigorous exercise should be
accorded a central place in the treatment of Parkinson's disease.
In this study, the investigators are to investigate the effect of regular vigorous aerobic
exercise training of running on motor and non-motor symptoms, and quality-of-life of people
with Parkinson's disease.
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