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Clinical Trial Summary

Impulse control disorders are frequent and troublesome in patients with Parkinson's disease. However, the cerebral functional alterations related to impulse control disorders in Parkinson's disease are poorly understood and may involve the serotoninergic system besides alterations in the dopaminergic system.

The primary objective of this study is to investigate the cerebral functional alterations in the serotoninergic system in patients with Parkinson's disease and impulse control disorders using Positron Emission Tomography with highly specific radiotracers of serotonin transporter (SERT) using [11 Carbon]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile ([11C]-DASB) and of serotonin 5-Hydroxytryptamine 2A (5-HT2A) receptor using [18 Fluorine]-altanserin ([18F]-altanserin), in comparison to patients with Parkinson's disease without impulse control disorders and healthy volunteers.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03970239
Study type Interventional
Source Hospices Civils de Lyon
Contact Stéphane THOBOIS, PhD
Phone 4 72 35 72 18
Email stephane.thobois@chu-lyon.fr
Status Recruiting
Phase N/A
Start date May 13, 2019
Completion date February 13, 2022

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