A Systematic Investigation of Phonetic Complexity Effects on Articulatory Motor Performance in Progressive Dysarthria

Parkinson Disease Clinical Trial

Official title:

Understanding Communication and Cognitive Impairments in Neurodegenerative Disorders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03613038
• Other study ID #: 1209643
• Secondary ID: 1R15DC016383-01
• Status: Completed
• Phase: N/A
• Start date: July 15, 2017
• Est. completion date: February 28, 2022

Study information

• Verified date: May 2022
• Source: University of Missouri-Columbia
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal is to improve the fundamental knowledge about articulatory motor performance in people with Lou Gehrig's disease (also known as ALS) and Parkinson's disease (PD), in order to develop more sensitive assessments for progressive speech loss, which may lead to the improved timing of speech therapies.

Description:

The long-term goal is to optimize dysarthria assessment by improving the early detection and tracking of articulatory performance in progressive dysarthrias. The short-term goal of the proposed cross-sectional study is to focus on ALS and PD and quantify articulatory kinematic performance as a function of phonetic complexity, which is experimentally manipulated based on theoretical principles of speech motor development. The research strategy is to use 3D electromagnetic articulography to examine phonetic complexity effects of single word stimuli at the articulatory kinematic level in 15 talkers each with preclinical, mild, and moderate dysarthria, relative to 45 controls. The central hypothesis is that as dysarthria severity increases the discrepancy in articulatory performance, indexed by movement speed, distance, coordination, and variability, between people with dysarthria and typical controls will significantly increase at a lower phonetic complexity level.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: February 28, 2022
• Est. primary completion date: February 28, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 19 Years to 90 Years

Eligibility

Inclusion Criteria:

1. May or may not have a neurological impairment.

2. Age range of 19-90 years.

3. Male or female.

4. Provide written consent before any study specific procedures are performed.

5. Have ability to comply with basic instructions.

6. Monolingual English speaker.

7. Have ability to partake in a 90 minute data collection.

Exclusion Criteria:

1. Any speech, language, cognition, or hearing impairment prior to diagnosis of a neurodegenerative disease.

2. Anyone not appropriate for study participation, as deemed by the principal investigator.

Related Conditions & MeSH terms

• Amyotrophic Lateral Sclerosis
• Dysarthria
• Motor Neuron Disease
• Parkinson Disease

Intervention

Behavioral:
• Phonetic complexity effects on speech motor performance
Use of 3D electromagnetic articulography to examine phonetic complexity effects of single word stimuli at the articulatory kinematic level in talkers each with preclinical, mild, and moderate dysarthria, relative to healthy controls.

Locations

Country	Name	City	State
United States	University of Missouri-Columbia	Columbia	Missouri
United States	University of Kansas Medical Center	Fairway	Kansas

Sponsors (2)

Lead Sponsor	Collaborator
University of Missouri-Columbia	National Institute on Deafness and Other Communication Disorders (NIDCD)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Peak movement speed	Peak speed (millimeters/second) for each articulatory marker is the maximum value of the first-order derivative of each marker's Euclidean distance time-history.	Up to 3 months after enrollment
Primary	Range of movement	The convex hull represents the smallest convex set containing all the points in the 3D motion path.	Up to 3 months after enrollment
Primary	Duration	Word duration (seconds) is the time between onset and offset of movement for each word.	Up to 3 months after enrollment
Primary	Spatiotemporal movement variability (STI)	STI is the most widely used metric to capture movement pattern variability during speech. To determine STI, the pattern of articulatory movements and the variability of that pattern over several repetitions of an utterance are examined.	Up to 3 months after enrollment
Primary	Inter-articulator coordination	Spatiotemporal coupling relations between articulators will be derived from vertical movements of the articulators using a covariance measure.	Up to 3 months after enrollment