Parkinson Disease Clinical Trial
Official title:
Prospective Study of Dysarthria, and the Appearance of Non-dopaminergic Signs in Idiopathic PARKinson's Disease
Pilot study:
- Longitudinal follow up of the PRODY-GI cohort for parkinson's disease (PD)
- Observational study of upper and lower axial symptoms' occurence in 30 PD patients in on
and off drug conditions, 30 aged matched control subjects and 10 control subjects with
supra nuclear palsy
- Multi modal approach: functional MRI, clinical , ENT assessment, respiratory assessment,
neuropsychological and gait evaluations
Prospective, clinical assessment of :
- Cognition and diadochokinetic task during fMRI in 30 PD patients (in off and on
condition)
- Motor assessment using VICON gait and balance analysis
- Pulmonary functional testing in OFF and ON drug condition
- Quality of life
- Clinical neurological MDS UPDRS , N Fog questionnaire
- ENT and speech therapist evaluation in OFF and ON drug condition
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