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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03476668
Other study ID # MIRT-RTs-Laterality
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 1, 2017
Est. completion date August 1, 2017

Study information

Verified date May 2018
Source Ospedale Generale Di Zona Moriggia-Pelascini
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The researchers aimed to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with Parkinson's disease (PD).


Description:

To bypass the impaired habitual motor-behavioural control, Parkinson's disease (PD) patients may exploit the network of goal-directed mode of action. The frontostriatal connections underline this functioning, that is based on attention. Since the cognitive processes are related with dopamine, the asymmetrical degeneration of the dopaminergic system affects differently the right side affected (RPD) and the left side affected (LPD) PD patients.

The aim of the study was to investigate the relationship between the asymmetric dopaminergic degeneration and the attentional resources in a group of patients with PD.


Recruitment information / eligibility

Status Completed
Enrollment 100
Est. completion date August 1, 2017
Est. primary completion date August 1, 2017
Accepts healthy volunteers No
Gender All
Age group 40 Years to 85 Years
Eligibility Inclusion Criteria:

- Stage 2.5-3 according to the Hoehn and Yahr scale (H&Y);

- Stable pharmacological treatment for the last 6 weeks before the enrolment and during the hospitalization;

- Mini Mental State Examination (MMSE) = 24;

- No evidences of dysexecutive syndrome.

Exclusion Criteria:

- Any focal brain lesion detected in brain imaging studies (CT or MRI) performed in the previous 12 months;

- Drug-induced dyskinesias;

- Disturbing resting and/or action tremor, corresponding to scores 2-4 in the specific items of UPDRS III;

- Behavioral disturbances (evaluated with Neuropsychiatric Inventory);

- Visual and auditory dysfunctions according to the general clinical evaluation and medical history;

- Equivocal report about the side of disease onset or bilateral motor involvement.

Study Design


Related Conditions & MeSH terms


Intervention

Other:
MIRT
4-week multidisciplinary intensive rehabilitation treatment

Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
Ospedale Generale Di Zona Moriggia-Pelascini

Outcome

Type Measure Description Time frame Safety issue
Primary Visual Reaction Times (V RTs) Visual Reaction Times 4 weeks
Primary Auditory Reaction Times (A RTs) Auditory Reaction Times 4 weeks
Primary Multiple Choices RTs (MC RTs) Multiple Choices RTs 4 weeks
Secondary Unified Parkinson's Disease Rating Scale (UPDRS) Unified Parkinson's Disease Rating Scale 4 weeks
Secondary Timed Up and Go Test (TUG) Timed Up and Go Test 4 weeks
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