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NCT03059212 Clinical Trial

rTMS in Facilitation of Working Memory in PD

Parkinson Disease Clinical Trial

Official title:
rTMS in Facilitation of Working Memory in PD

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT03059212
Other study ID # 2014-10-018A
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date October 30, 2017
Est. completion date December 2021

Study information
Verified date January 2021
Source Taipei Veterans General Hospital, Taiwan
Contact Po-Yi Tsai, MD
Phone 886-22875729
Email vivitsai0518@gmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.

Description:

Excitatory (>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal cortex.

Recruitment information / eligibility
Status Recruiting
Enrollment 60
Est. completion date December 2021
Est. primary completion date December 2021
Accepts healthy volunteers No
Gender All
Age group 30 Years to 85 Years
Eligibility Inclusion Criteria: - Clinical diagnosis of Parkinson's Disease - With symptoms of cognitive impairments, such as memory, attention, or language decline. Exclusion Criteria: - History of seizure attack - Alzheimer's disease - With cardiac pacemaker implantation

Study Design

Related Conditions & MeSH terms

Intervention

Device:
• rTMS
High frequency rTMS for 3 to 10 min to increase the excitability of cortex.
Behavioral:
• Cognitive training program
A rehabilitation protocol that facilitates attention, memory, execution.

Locations
Country Name City State
Taiwan Taipei Veteran General Hospital Taipei

Sponsors (1)
Lead Sponsor Collaborator
Taipei Veterans General Hospital, Taiwan

Country where clinical trial is conducted

Taiwan, 

References & Publications (1)

Preston G, Anderson E, Silva C, Goldberg T, Wassermann EM. Effects of 10 Hz rTMS on the neural efficiency of working memory. J Cogn Neurosci. 2010 Mar;22(3):447-56. doi: 10.1162/jocn.2009.21209. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Change of Repeatable Battery for the Assessment of Neuropsychological Status This battery measures the cognitive functions including attention, memory, language, visuospatial domains. up to 12 weeks
Secondary Change of Montreal Cognitive Assessment ; MoCA Assessing cognitive function including delaying recall, attention, executive function, language... up to 12 weeks
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