Strength Training and Different Subtypes of Parkinson´s Disease

Parkinson Disease Clinical Trial

Official title:

Effects of Progressive Resistance Exercise in Akinetic-rigid Parkinson's Disease Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02966600
• Other study ID #: UOviedo
• Status: Completed
• Phase: N/A
• First received: November 7, 2016
• Last updated: November 14, 2016
• Start date: February 2016
• Est. completion date: April 2016

Study information

• Verified date: November 2016
• Source: University of Oviedo
• Contact: n/a
• Is FDA regulated: No
• Health authority: Spain: Ministry of Health
• Study type: Interventional

Clinical Trial Summary

The aim of this randomized controlled trial was to assess the impact of progressive resistance exercise (PRE) in PD patients with akinesia and rigidity (AR-subtype). The investigators hypothesized the intervention would have a beneficial effect on the study outcomes.

Description:

Twenty-eight patients with PD AR-type of both sexes, were recruited for this trial. Each participant were assigned randomly to either intervention (N=13) or control (N=15) group.

The intervention group participated in sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one. The control group followed their usual weekly physical activity routine.

All patients underwent antrophometrical and neuromuscular function assessment (CoP measurements -primary outcomes- and the Ten-Meters Walk Test -TMWT- -secondary outcomes-). In addition, they were asked to provide ratings for the Spanish validated versions of the the Freezing of Gait Questionnaire (FOG-Q, 6-item version) -secondary outcomes-, the 39-item Parkinson ́s disease Questionnaire (PDQ39) -secondary outcomes- and the MDS-UPDRS -secondary outcomes-. Additionally, ratings of perceived exertion (RPE) (Borg >6-20 scale) - secondary outcomes-, were recorded at the end of each PRE training session. Tests were carried out at three times: pre-test (before the training program), post-test (eight weeks after pre-tests, at the end of the training period), and four weeks after the post-test (re-test).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28
• Est. completion date: April 2016
• Est. primary completion date: April 2016
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Diagnosed with PD AR-type and Hoehn and Yahr Scale 1-2, (H&Y)

• Do not express any type of dementia

• Able to stand for two min without assistance;

• Able to walk ten metres without assistance.

Exclusion criteria:

• To suffer a neurological disease other than PD.

• Do not meet some of the inclusion criteria.

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Supportive Care

Related Conditions & MeSH terms

• Parkinson Disease

Intervention

Other:
• Progressive resistance exercise
The intervention group participated in sixteen PRE training sessions for eight weeks: two sessions per week on non-consecutive days, sixty-seventy min each one.
• Physical Activity
The control group followed its usual weekly physical activity routine

Locations

Country	Name	City	State
Spain	University School of Sports Medicine, University of Oviedo, Spain.	Oviedo	Asturias

Sponsors (1)

Lead Sponsor	Collaborator
University of Oviedo

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Static posturography through the centre of pressures measurements (CoP).		Eight weeks	Yes
Secondary	Gait.		Eight weeks	Yes
Secondary	Freezing of gait.		Eight weeks	Yes
Secondary	The Movement Disorders Society-Unified Parkinson ´s Disease Rating Scale. (MDS-UPDRS).		Eight weeks	Yes
Secondary	The patient- perceived quality of life.		Eight weeks	Yes