Parkinson Disease Clinical Trial
Official title:
Motor Response to Dopaminergic Therapy in a Population of de Novo Parkinson's Disease Cases Quantified Via Typing Analyses - -neuroQWERTY
The motor impairment produced by Parkinson's disease (PD) is a significant and debilitating
part of the condition. Current methods to evaluate this impairment rely on subjective
examinations. The investigators seek to develop an objective assessment of motor deficits by
monitoring the participants natural interactions with a keyboard (on a computer or smart
device). This approach provides a window to how the brain behaves during typical daily use of
these devices, i.e. writing a report, sending an email or any other task performed on a
digital device and thus has the potential to be used easily and regularly. (Importantly, the
data gathered are non-sensitive and based only on timing information).
PD participants will be recruited during outpatient visits to PD clinics throughout the
Madrid metropolitan region. General entry criteria will be those patients who are scheduled
to begin dopaminergic therapy, and own a home computer or laptop. The study will not impact
on participants' standard clinical management other than by asking the participants to type
for 15 minutes at each of the clinic visits, and installing the investigators proprietary
software on their home computer. This software will collect keystroke data alone. (None of
the actual information about what is being typed will be collected.) The keystroke data
collected will be analyzed and compared with standard clinical metrics of therapeutic
response, as well as the in-clinic typing data.
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