Parkinson Disease Clinical Trial
— PDWMOfficial title:
Beyond the Physical: Enhancing Psychosocial Functioning in Parkinson's Disease
Verified date | May 2023 |
Source | Nova Scotia Health Authority |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This project will investigate the feasibility and preliminary effectiveness of an intensive and focused working memory training program for patients in the early stages of PD receiving dopaminergic therapy. The investigators hypothesize that working memory training will be an effective method of improving working memory and related cognitive and behavioural functions in PD patients.
Status | Active, not recruiting |
Enrollment | 30 |
Est. completion date | December 31, 2024 |
Est. primary completion date | December 31, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - clinical diagnosis of idiopathic Parkinson's disease - self-reported concerns about their working memory, or working memory deficits that were identified by a clinical examination - be classified as Hohn & Yahr Stage 1 or 2 - be receiving a stable dose of dopaminergic therapy Exclusion Criteria: - presence of dementia or other significant neurological or psychiatric conditions, as determined by clinical history - Classification as Hohm & Yahr Stage 3 or 4 - Not on a stable dos of dopaminergic therapy |
Country | Name | City | State |
---|---|---|---|
Canada | Dalhousie University | Halifax | Nova Scotia |
Lead Sponsor | Collaborator |
---|---|
Gail Eskes | Nova Scotia Health Authority |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Baseline Working memory function | Working memory will be measured using the operation span task, the symmetry span task and the Sternberg memory scanning tasks. Operation span - This is a dual-task in which participants complete mathematical reasoning (e.g. solving a mathematical equation) while using short-term verbal memory to remember words. Symmetry span: This is a dual task in which participants discriminate about the symmetry of visual stimuli while using short-term spatial memory to remember the locations of stimuli. Sternberg memory scanning task - number memory test |
baseline | |
Primary | Change in working memory function between baseline and 5 weeks post training onset | 5 weeks post training onset | ||
Primary | Change in working memory function between baseline and 10 weeks post training onset | 10 weeks post training onset | ||
Primary | Change in working memory function between baseline and 22 weeks post training onset | 22 weeks post training onset | ||
Secondary | Baseline fluid intelligence | Fluid intelligence will be measured using Cattell's Culture Fair Intelligence Test, a measure of analogical reasoning, and Raven's Progressive Matrices, a measure of spatial reasoning. | Baseline | |
Secondary | change in fluid intelligence between baseline and 5 weeks post training onset | 5 weeks post training onset | ||
Secondary | Change in fluid intelligence between baseline and 10 weeks post training onset | 10 weeks post training onset | ||
Secondary | Change in fluid intelligence between baseline and 22 weeks post training onset | 22 weeks post training onset | ||
Secondary | Baseline Executive functioning | Executive functioning will be measured using the Dysexecutive Questionnaire. It is a self-report and other-report of everyday behaviours reflecting executive function. | Baseline | |
Secondary | Change in executive functioning between baseline and 5 weeks post training onset | 5 weeks post training onset | ||
Secondary | Change in executive functioning between baseline and 10 weeks post training onset | 10 weeks post training onset | ||
Secondary | Change in executive function between baseline and 22 weeks post training onset | 22 weeks post training onset |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05415774 -
Combined Deep Brain Stimulation in Parkinson's Disease
|
N/A | |
Recruiting |
NCT04691661 -
Safety, Tolerability, Pharmacokinetics and Efficacy Study of Radotinib in Parkinson's Disease
|
Phase 2 | |
Active, not recruiting |
NCT05754086 -
A Multidimensional Study on Articulation Deficits in Parkinsons Disease
|
||
Completed |
NCT04045925 -
Feasibility Study of the Taïso Practice in Parkinson's Disease
|
N/A | |
Recruiting |
NCT04194762 -
PARK-FIT. Treadmill vs Cycling in Parkinson´s Disease. Definition of the Most Effective Model in Gait Reeducation
|
N/A | |
Completed |
NCT02705755 -
TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH)
|
Phase 2 | |
Terminated |
NCT03052712 -
Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
|
N/A | |
Recruiting |
NCT05830253 -
Free-living Monitoring of Parkinson's Disease Using Smart Objects
|
||
Recruiting |
NCT03272230 -
Assessment of Apathy in a Real-life Situation, With a Video and Sensors-based System
|
N/A | |
Recruiting |
NCT06139965 -
Validity and Reliability of the Turkish Version of the Comprehensive Coordination Scale in Parkinson's Patients
|
||
Completed |
NCT04580849 -
Telerehabilitation Using a Dance Intervention in People With Parkinson's Disease
|
N/A | |
Completed |
NCT03980418 -
Evaluation of a Semiconductor Camera for the DaTSCAN™ Exam
|
N/A | |
Completed |
NCT04477161 -
Effect of Ketone Esters in Parkinson's Disease
|
N/A | |
Completed |
NCT04942392 -
Digital Dance for People With Parkinson's Disease During the COVID-19 Pandemic
|
N/A | |
Terminated |
NCT03446833 -
LFP Beta aDBS Feasibility Study
|
N/A | |
Completed |
NCT03497884 -
Individualized Precise Localization of rTMS on Primary Motor Area
|
N/A | |
Completed |
NCT05538455 -
Investigating ProCare4Life Impact on Quality of Life of Elderly Subjects With Neurodegenerative Diseases
|
N/A | |
Recruiting |
NCT04997642 -
Parkinson's Disease and Movement Disorders Clinical Database
|
||
Completed |
NCT04117737 -
A Pilot Study of Virtual Reality and Antigravity Treadmill for Gait Improvement in Parkinson
|
N/A | |
Recruiting |
NCT03618901 -
Rock Steady Boxing vs. Sensory Attention Focused Exercise
|
N/A |