Parkinson Disease Clinical Trial
Official title:
Changes of the Neuronal Activity in the Subthalamic Nucleus Under Propofol Sedation During Stereotactic Electrode Implantation.
The purpose of this study is to detect possible changes in the electrical activity of the Basal Ganglia related to sedation during deep brain stimulation surgery.
Deep Brain Stimulation is commonly used for the treatment of movement disorders. Electrode
positioning is usually performed under local anesthesia in fully awake patients. The
procedure is uncomfortable to the patients who have to remain motionless during the whole
surgery. Previous reports of electrode positioning under general anesthesia was found to be
less accurate. This result was probably due to the effect of the anesthetics on the
electrical activity of the Basal Ganglia.
The purpose of this study is to detect possible changes in the electrical activity of the
Basal Ganglia related to propofol sedation. Electrical activity of single neurons will be
recorded before and after sedation.
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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