Parkinson Disease Clinical Trial
Official title:
Can Subthreshold Transcranial Magnetic Stimulation (rTMS) to Motor Cortex and/or to Supplementary Motor Area (SMA) Improve Performance of Complex Motor Sequences in Parkinson's Disease?
The problems in motor activity associated with Parkinson's disease are still poorly
understood. Patients with Parkinson's disease often suffer from extremely slow movements
(bradykinesia) which result in the inability to perform complex physical acts.
Imaging studies of the brain have provided researchers with information about the specific
areas in the brain associated with these motor difficulties. One particular area involved is
the surface of the brain called the cerebral cortex.
Transcranial Magnetic Stimulation (TMS) is a non-invasive technique that can be used to
stimulate brain activity and gather information about brain function. It is very useful when
studying the areas of the brain related to motor activity (motor cortex, corticospinal
tract, and corpus callosum). Repetitive transcranial magnetic stimulation (rTMS) involves
the placement of a cooled electromagnet with a figure-eight coil on the patient's scalp and
rapidly turning on and off the magnetic flux. This permits non-invasive, relatively
localized stimulation of the surface of the brain (cerebral cortex). The effect of magnetic
stimulation varies, depending upon the location, intensity and frequency of the magnetic
pulses.
Researchers plan to study the therapeutic effects of repetitive transcranial magnetic
stimulation (rTMS) on complex motor behavior of patients with Parkinson's disease. In order
to measure its effectiveness, patients will be asked to perform complex tasks, such as
playing the piano while receiving transcranial magnetic stimulation.
Status | Completed |
Enrollment | 12 |
Est. completion date | September 2000 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | N/A and older |
Eligibility |
Patients with PD. No epilepsy. No seizures. No metal in the head. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Bergman H, Wichmann T, DeLong MR. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science. 1990 Sep 21;249(4975):1436-8. — View Citation
DeLong MR. Primate models of movement disorders of basal ganglia origin. Trends Neurosci. 1990 Jul;13(7):281-5. Review. — View Citation
Playford ED, Jenkins IH, Passingham RE, Nutt J, Frackowiak RS, Brooks DJ. Impaired mesial frontal and putamen activation in Parkinson's disease: a positron emission tomography study. Ann Neurol. 1992 Aug;32(2):151-61. — View Citation
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