Pancreatic Ductal Adenocarcinoma Clinical Trial
Official title:
Generation of Patient Derived Pancreatic Cancer Cell Lines to Determine Mechanisms of Chemoresistance
This pilot research trial studies patient derived cancer cell lines in identifying molecular changes in patients with previously untreated pancreatic cancer and are receiving gemcitabine hydrochloride-based chemotherapy. Cell lines refer to samples taken from the patient's tumor to grow for many months or years in a laboratory, and can therefore be studied scientifically. Studying cell lines in the laboratory may help doctors understand the genetic changes that occur to the tumor during chemotherapy that allows the tumor to resist or grow despite treatment.
PRIMARY OBJECTIVES:
I. Compare the genetic profile of the tumor after progression has occurred, to the tumor
prior to treatment.
SECONDARY OBJECTIVES:
I. Additional molecular patterns, beyond genetics, will be analyzed, including ribonucleic
acid (RNA) and protein expression.
OUTLINE:
Tissue and blood samples are collected for genetic analysis via sequencing from patients
receiving gemcitabine hydrochloride intravenously or gemcitabine hydrochloride and paclitaxel
albumin-stabilized nanoparticle formulation. Chemotherapy is not part of the protocol. Per
standard of care, patients receive gemcitabine hydrochloride (IV) the first 3 of 4 weeks (qw
3/4 wk) or gemcitabine hydrochloride and paclitaxel albumin-stabilized nanoparticle
formulation IV qw 3/4 wk in the absence of disease progression or recurrence.
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