Pancreatic Cancer Clinical Trial
Official title:
Phase Ⅰ/Ⅱ Trial of Human Leukocyte Antigen (HLA)-A*2402-Restricted Vascular Endothelial Growth Factor Receptor 1 (VEGFR1)-Derived Peptide Vaccination Combined With Gemcitabine for Advanced Pancreatic Cancer
Feasibility and efficacy of combined modality intervention using chemotherapeutic agent
gemcitabine with anti-angiogenic peptide vaccination targeting VRGFR1 should be determined in
case of advanced/inoperable or therapy-resistant pancreatic cancer patients.
Gemcitabine 1,000mg/m2 BSA will be administered on day1, day8, day15, day29, day36, day43,
respectively.
HLA-A*2402-restricted VEGFR1-derived peptide (VEGFR1-A24-1084; SYGVLLWEI) emulsified with
Montanide ISA51 will be subcutaneously injected twice weekly for 8weeks (total 16 doses).
HLA-A*2402-restricted cytotoxic T lymphocyte (CTL) clones were obtained from healthy
volunteer donor peripheral blood.
These CTL clones showed potent cytotoxicities selectively against VEGFR1-expressing target
cells in HLA-class I-restricted manner.
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