Pancreatic Cancer Clinical Trial
Official title:
Use of Serum Proteome on the Early Diagnosis of Malignant Biliary-Pancreatic Disease
RATIONALE: Studying samples of blood in the laboratory from patients with cancer and from
healthy participants may help doctors identify and learn more about proteins related to
cancer. It may also help doctors tell whether a patient has cancer.
PURPOSE: This clinical trial is looking at proteins in blood samples to see how well they
work in finding pancreatic cancer and extrahepatic biliary tract cancer.
OBJECTIVES:
- To explore the utility of the serum proteome pattern for early detection and diagnosis
of pancreatic and extraheptic biliary tract cancer by analyzing serum samples from
participants previously enrolled in the PANKRAS-II study.
- To support efforts to contact participants (recruited to the PANKRAS-II study 10 years
ago) who were diagnosed with benign biliary-pancreatic disease in order to discern if
they subsequently developed a malignant biliary-pancreatic tumor.
- To gather information about clinical factors surrounding the date of blood extraction
that may influence the proteomic patterns of the blood samples by performing a review
of clinical records of participants.
OUTLINE: Serum samples are analyzed for proteome pattern. Participants undergo a telephone
interview about their medical history (i.e., pancreatic or biliary tract disease diagnosed
within the past 10 years). Medical records are reviewed to gather information about clinical
factors surrounding the date of blood extraction that may influence the proteomic patterns
of the blood samples.
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