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Clinical Trial Summary

This study is an open-label, parallel, 2-cohort, multicenter, investigator-initiated Phase 2 trial to evaluate the efficacy and safety of binimetinib in patients with advanced or recurrent low-grade glioma or pancreatic cancer harboring BRAF fusion/rearrangement.


Clinical Trial Description

This study is an open-label, parallel, 2-cohort, multicenter, investigator-initiated Phase 2 trial. Eligible patients are with recurrent low-grade glioma (grade 1 and grade 2 tumors according to WHO classification) or advanced or recurrent pancreatic cancer harboring BRAF fusion/rearrangement. Patients receive binimetinib 45mg administered orally, twice daily. Analyses will be performed on each of the two cohorts: Cohort A: low-grade glioma Cohort B: pancreatic cancer ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06159478
Study type Interventional
Source National Cancer Center, Japan
Contact Chigusa Morizane, M.D., Ph.D.
Phone 0335422511
Email ncch2101_office@ml.res.ncc.go.jp
Status Recruiting
Phase Phase 2
Start date March 29, 2023
Completion date September 30, 2027

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