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Clinical Trial Summary

Patients with advanced pancreas adenocarcinoma will be randomized on a 6:1 basis to receive standard of care chemotherapy followed by adaptive stereotactic body radiotherapy (SBRT) with concurrent and adjuvant FAK inhibitor defactinib (experimental arm) or standard of care chemotherapy followed by SBRT (control arm). Patients enrolled to the experimental arm will be assessed for clinical outcomes such as progression free survival (PFS), local control, distant control, and toxicity. The first 6 patients randomized to the experimental arm will be considered the safety lead-in and will be assessed for dose-limiting toxicities (DLTs). The 6 patients randomized to the control arm will be evaluated for correlatives but will not be included in the analysis for primary and secondary endpoints.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04331041
Study type Interventional
Source Washington University School of Medicine
Contact Hyun Kim, M.D.
Phone 314-362-8502
Email kim.hyun@wustl.edu
Status Recruiting
Phase Phase 2
Start date August 24, 2021
Completion date December 31, 2026

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