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Test Retest Reliability of OA and OH

Pain Clinical Trial

Official title:
Test Retest Reliability of Offset Analgesia and Onset Hyperalgesia Paradigm

Clinical Trial Summary

The goal of this study is to measure the test retest reliability of offset analgesia (OA) and onset hyperalgesia (OH) across multiple study visits. OA and OH are quantitative sensory tests (QST) thought to measure how the brain modulates pain. This study will use a heat thermode to induce OA and OH in healthy, pain-free volunteers across 3 study visits. Additional QST measures and survey data relevant to pain modulation will be collected. This study lays the foundation required to use OA and OH as tools to measure pain modulation in clinical trials. Following their validation, we anticipate that OA and OH will serve as predictive and therapeutic biomarkers, which will aid both in the development of novel analgesics and in treatment selection leading to the personalization of pain management.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05487183
Study type Interventional
Source University of Pittsburgh
Contact
Status Completed
Phase N/A
Start date August 5, 2022
Completion date April 10, 2024
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