Pain Clinical Trial
Official title:
The Influence of Cardiovascular Autonomic Function on Endogenous Pain Modulation Before and After Exercise and Cognitive Task in Fibromyalgia
The study has three aims:
1. To investigate the influence of cardiovascular autonomic function on pain sensitivity at
rest in patients with fibromyalgia and age- and sex-matched controls
2. To investigate the influence of cardiovascular autonomic function at baseline and during
exercise on the pain response following submaximal isometric exercise
3. To study the relation between the pain response following physical and cognitive tasks
(exercise and mental math, respectively).
Fibromyalgia (FM) affects 2 -8% of the population with a higher prevalence in women than men.
People with FM report widespread pain that impacts their quality of life. Patients may also
experience other symptoms besides pain such as depression, anxiety, fatigue, sleep
difficulties and others. Exercise is one of the interventions that have been shown to reduce
pain in chronic pain populations. The phenomenon by which exercise reduces pain sensitivity
is known as exercise-induced hypoalgesia (EIH). Although exercise is strongly recommended by
American Pain Society guideline for the treatment of FM, some patients with FM report an
increase in pain and worsening symptoms following acute exercise. The worsening of symptoms
may impact adherence to exercise training. Why some people with FM report pain exacerbation
while others report pain relief following exercise is not known.
This study aims at assessing the influence of the cardiovascular autonomic nervous system on
pain sensitivity at rest and following exercise in patients with fibromyalgia and pain-free
individuals.
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