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Clinical Trial Summary

The study has three aims:

1. To investigate the influence of cardiovascular autonomic function on pain sensitivity at rest in patients with fibromyalgia and age- and sex-matched controls

2. To investigate the influence of cardiovascular autonomic function at baseline and during exercise on the pain response following submaximal isometric exercise

3. To study the relation between the pain response following physical and cognitive tasks (exercise and mental math, respectively).


Clinical Trial Description

Fibromyalgia (FM) affects 2 -8% of the population with a higher prevalence in women than men. People with FM report widespread pain that impacts their quality of life. Patients may also experience other symptoms besides pain such as depression, anxiety, fatigue, sleep difficulties and others. Exercise is one of the interventions that have been shown to reduce pain in chronic pain populations. The phenomenon by which exercise reduces pain sensitivity is known as exercise-induced hypoalgesia (EIH). Although exercise is strongly recommended by American Pain Society guideline for the treatment of FM, some patients with FM report an increase in pain and worsening symptoms following acute exercise. The worsening of symptoms may impact adherence to exercise training. Why some people with FM report pain exacerbation while others report pain relief following exercise is not known.

This study aims at assessing the influence of the cardiovascular autonomic nervous system on pain sensitivity at rest and following exercise in patients with fibromyalgia and pain-free individuals. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03911609
Study type Interventional
Source Marquette University
Contact Marie K Hoeger Bement, PT, PhD
Phone 414-288-6738
Email mariehoeger.bement@marquette.edu
Status Recruiting
Phase N/A
Start date March 20, 2019
Completion date December 30, 2022

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