Pain Clinical Trial
Official title:
Impact of Somatic Yoga and Meditation on Fall Risk, Function, and Quality of Life for Chemotherapy-Induced Peripheral Neuropathy Syndrome in Cancer Survivors
Chemotherapy-induced peripheral neuropathy syndrome (CIPN) causes significant pain in hands and feet and is an adverse effect of treatment. Few non-pharmacological interventions have been tested and individuals experience CIPN symptoms years after treatment. This is the first study to explore a somatic yoga and meditation (SYM) intervention on functional outcomes and quality of life in cancer survivors.
Pain is a common symptom associated with cancer; 75-90% of cancer patients experience pain
during their illness and up to 50% of that pain is undertreated. Unrelieved pain leads to
increased levels of the stress hormone cortisol. Chemotherapy-induced peripheral neuropathy
syndrome (CIPN) causes significant pain in hands and feet and is a common, adverse effect of
several chemotherapeutic agents. It can lead to abrupt discontinuation of treatment, and
severely affects the quality of life.
CIPN is a particularly important adverse effect because it may compromise the ability to
tolerate chemotherapy and become a serious, long-lasting, and even permanent debility. CIPN
symptoms may persist many years after treatment; together with worse function, greater
disability, and more falls which is complicated by the aging process. Clinically, CIPN
presents as deficits in sensory, motor, and function which develop in a glove and stocking
distribution.
While chemotherapy improves the likelihood of disease-free survival, the result of CIPN may
cause decreased walking speed and balance observed after the first chemotherapy cycle and
progresses with cumulative exposure. These functional deficits are mirrored with increased
symptom severity. CIPN is associated with potential fall risk with aging cancer survivors and
increased functional disability.
Few interventions have been tested for impact from CIPN. Yoga is a popular movement therapy,
often used by cancer survivors for symptom management. Several studies demonstrate the
promising effects of yoga on sleep, fatigue and quality of life (QOL) in cancer survivors.
However, no study has rigorously investigated its effects on CIPN and quality of life.
This study will explore the preliminary therapeutic effects of an 8-week somatic based yoga
and meditation (SYM) program and 15-25 cancer survivors with CIPN will be enrolled into a
small pilot study. This will include 16 sessions of yoga designed specifically to minimize
injury, promote flexibility/ balance and to allow you to maximize their specific functional
goals. All types of cancer diagnoses resulting in CIPN will be enrolled in a single arm
feasibility trial. SYM will be provided twice a week for 8 weeks for 1.5 hours. You will
complete surveys at the beginning and end of 8 weeks and receive a home-based SYM and write
journal entries to determine your perspectives of the intervention.
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