The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population

Pain Clinical Trial

Official title:

The Possible Correlations Between the Genes Related to Pain Sensation and the Pain Sensitivity in the General Population

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01950078
• Other study ID #: Gene and Pain
• Status: Completed
• Phase: N/A
• First received: September 23, 2013
• Last updated: February 12, 2015
• Start date: August 2013
• Est. completion date: December 2014

Study information

• Verified date: February 2015
• Source: Huazhong University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Food and Drug Administration
• Study type: Observational

Clinical Trial Summary

Objective: This study was conducted to explore the possible correlation between some gene related to pain sensation and individual basal pain perception and postoperative pain intensity in the general population. Methods: Patients receiving elective surgery under general anesthesia were recruited into this study. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). Pain intensity at rest and movement after the operation was evaluated . And the PCA drug consumption were recorded. Also there were healthy college students volunteer be recruited into this study. The investigators measured their experimental pain sensitivity including pressure pain threshold (PPT) and pressure pain tolerance (PTO), etc. Then genotyping was carried out.

Description:

Subjects with the following diseases were excluded: known history of chronic disease, psychiatric diseases or communication disorders, diabetes mellitus, severe cardiovascular diseases, kidney or liver diseases with poor hepatic function, alcohol or drug abuse, heavy smoker, Pregnancy or at lactation period .

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1533
• Est. completion date: December 2014
• Est. primary completion date: August 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• •Aged 18-65 years

• Receiving elective gynecological laparoscopic surgery

• Anesthesiologists (ASA) physical status I or II

• Agreed to participate the research

Exclusion Criteria:

• •History of chronic pain

• Psychiatric diseases

• Diabetes mellitus

• Severe cardiovascular diseases

• Kidney or liver diseases

• Alcohol or drug abuse

• Heavy smoker

• Pregnancy or at lactation period

• Disagree to participate to the research

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Pain
• Surgery

Locations

Country	Name	City	State
China	Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology	Wuhan	Hubei

Sponsors (1)

Lead Sponsor	Collaborator
Xianwei Zhang

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Preoperative Pressure Pain Threshold (PPT)	The probe of pressure algometer was positioned perpendicularly to the skin surface of the patient, and the investigator applied continuous pressure at approximately the same rate according to the visual LCD display on the algometer. subjects were asked to say "pain" when they started to feel pain during the stimulation. The value from the LCD was recorded as the pressure pain threshold.	30 minutes before the operation	Yes
Secondary	Preoperative Pressure Pain Tolerance (PTO)	The probe of pressure algometer was positioned perpendicularly to the skin surface of the patient, and the investigator applied continuous pressure at approximately the same rate according to the visual LCD display on the algometer. subjects were asked to say "ok" when they started to feel the pain became intolerable during the stimulation. The value from the LCD was recorded as the pressure pain tolerance.	30 minutes before the operation	Yes