Pain Clinical Trial
Official title:
Corticosteroids for Cancer Pain
Study hypothesis: corticosteroids are effective for pain in cancer patients. We will perform a double-blind, randomized, placebo-controlled multicentre trial evaluating the effect of Methylprednisolone 16 mg twice daily in cancer patients with pain (average pain last 24 hrs NRS > 4 (Numerical rating scale, 0 No pain, 10 worst pain).
Patients are required to use strong opioids before entering the study. Weak opioids are
allowed if patients have short acting strong opioids as rescue-medication. The scheduled
opioids shall be stable last 48 hours before entering the study and will be kept stable
during the study period. Patients may use as much short acting rescue-medication as they
require. No other analgesic medication should be started during the study period.
The study is a multicentre trial. Patients will be randomized according to 1. study centre
(No 1-5) and 2. pain mechanism: skeletal metastases (yes/no).
Patients are evaluated Day 0 and Day 7 by palliative care physician. Patients will be
contacted by phone Day 1-6 and will fill in questionnaire regarding symptoms and analgesic
usage. Patients will be contacted Day 14 and 21 to fill in questionnaires regarding symptoms,
quality of life and side effects.
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