A Study of Rofecoxib in the Treatment of Post-Operative Pain After Total Knee Joint Replacement (0966-259)

Pain Clinical Trial

Official title:

A Study to Compare Pre-Operative Administration of Rofecoxib Vs Post-Operative Administration of Diclofenac or Rofecoxib in the Treatment of Post-Operative Pain After Total Knee Joint Replacement in Patients With Osteoarthritis of the Knee.

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT00140920
• Other study ID #: 0966-259
• Secondary ID: 2005_054
• Status: Terminated
• Phase: Phase 4
• First received: August 30, 2005
• Last updated: May 5, 2017
• Start date: May 25, 2004
• Est. completion date: September 27, 2004

Study information

• Verified date: May 2017
• Source: Merck Sharp & Dohme Corp.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A study to compare pre-operative administration of rofecoxib versus post-operative administration of diclofenac or rofecoxib, respectively, in the treatment of post-operative pain after total knee joint replacement in patients with osteoarthritis of the knee.

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 11
• Est. completion date: September 27, 2004
• Est. primary completion date: September 27, 2004
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Males or females at least 18 years of age who have osteoarthritis of the knee and have undergone total knee joint replacement.

Related Conditions & MeSH terms

• Pain
• Pain, Postoperative

Intervention

Drug:
• MK0966; rofecoxib

• Comparator: diclofenac 2x 75 mg

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Merck Sharp & Dohme Corp.

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Quantity of patient controlled
Primary	Post-operative morphine administration