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NCT05669924 Clinical Trial

Neural Correlates of Acute Pain Dynamics

Pain Clinical Trial

Official title:
The Neural Correlates of and Effects of Methylphenidate on Acute Pain Dynamics

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05669924
Other study ID # STU00213557
Secondary ID
Status Completed
Phase Phase 2
First received
Last updated
Start date September 19, 2022
Est. completion date April 26, 2024

Study information
Verified date April 2024
Source Northwestern University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This work aims to study the neural correlates and determinants of pain dynamics related to changes in a noxious stimulus.

Recruitment information / eligibility
Status Completed
Enrollment 40
Est. completion date April 26, 2024
Est. primary completion date April 26, 2024
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 65 Years
Eligibility Inclusion Criteria: - Exclusion Criteria: - Pregnant - History of chronic pain - History of neurological diagnosis - History of psychiatric diagnosis

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Methylphenidate
0.35 mg/kg methylphenidate will be administered after baseline testing and 45 min-1 hr before post-intervention testing.
• Placebo
Placebo for methylphenidate

Locations
Country Name City State
United States Northwestern University Chicago Illinois

Sponsors (2)
Lead Sponsor Collaborator
Northwestern University National Institute of Neurological Disorders and Stroke (NINDS)

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary Effect of methylphenidate on acute pain dynamics We will compare acute pain dynamics-i.e., the time series of pain visual analog scale ratings (0-100, where 0 = no pain and 100 = worst pain imaginable) obtained while delivering a changing noxious stimulus-during the methylphenidate condition to that of the placebo condition. 6 months
Primary Nucleus accumbens activation with acute pain dynamics We will regress the time course of nucleus accumbens BOLD activity onto the latent time series obtained from our valence competition model. This will be supported by regressing the nucleus accumbens time course onto the pain VAS time course, allowing our findings to be compared to standard analyses in the literature. 6 months
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