Pain Clinical Trial
Official title:
Comparison of Intravenous Push Dose of Low Dose Ketamine to Short Infusion of Low Dose Ketamine for Treatment of Moderate to Severe Pain in the Emergency Department: A Prospective, Randomized, Double-Blind Study
Verified date | October 2017 |
Source | Maimonides Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Our previous published research comparing the efficacy of intravenous ketamine to morphine has shown ketamine to provide equivalent relief of moderate to severe acute pain in emergency medicine patients. Secondary analysis of the previous published research has also revealed ketamine to have statistically more side effects. The investigators believe that increasing the time of administration of the ketamine, from a push injection to a drip infusion, will minimize the side effects experienced by recipients of ketamine.
Status | Completed |
Enrollment | 48 |
Est. completion date | February 28, 2017 |
Est. primary completion date | August 15, 2016 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Emergency Medicine patients - Adult patients (18-65 years of age) - Moderate to severe pain (Numeric Pain Rating Score =5). - Patients must be awake, alert and oriented to time, place and person. - Patients must be able to demonstrate understanding of the informed consent, and also able to verbalize how much pain they are having on the 10 point Numeric Rating Pain Scale, and the nature of the side effects they may be experiencing from the IV analgesia Exclusion Criteria: - Patients with cognitive deficits that are not able to demonstrate understanding as described above. - Patient's reported weight of less than 45kg or more than 115kg. - Patients with altered mental status, alcohol intoxication, eye trauma. - Patients with hemodynamic instability (Systolic Blood pressure <90), and malignant hypertension. - allergy to ketamine - Pregnancy or breast feeding. |
Country | Name | City | State |
---|---|---|---|
United States | Maimonides Medical Center | Brooklyn | New York |
Lead Sponsor | Collaborator |
---|---|
Antonios Likourezos |
United States,
1. Abdullah M. Ketamine. A new look at an old drug. M ABDULLAH. anaesthetics.ukzn.ac.za/.../Ketamine_a_new_look_at_an_old_drug_...(accessed on 12/21/11)
Galinski M, Dolveck F, Combes X, Limoges V, Smaïl N, Pommier V, Templier F, Catineau J, Lapostolle F, Adnet F. Management of severe acute pain in emergency settings: ketamine reduces morphine consumption. Am J Emerg Med. 2007 May;25(4):385-90. — View Citation
Gurnani A, Sharma PK, Rautela RS, Bhattacharya A. Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine. Anaesth Intensive Care. 1996 Feb;24(1):32-6. — View Citation
Javery KB, Ussery TW, Steger HG, Colclough GW. Comparison of morphine and morphine with ketamine for postoperative analgesia. Can J Anaesth. 1996 Mar;43(3):212-5. — View Citation
Lester L, Braude DA, Niles C, Crandall CS. Low-dose ketamine for analgesia in the ED: a retrospective case series. Am J Emerg Med. 2010 Sep;28(7):820-7. doi: 10.1016/j.ajem.2009.07.023. Epub 2010 Apr 2. — View Citation
Richards JR, Rockford RE. Low-dose ketamine analgesia: patient and physician experience in the ED. Am J Emerg Med. 2013 Feb;31(2):390-4. doi: 10.1016/j.ajem.2012.07.027. Epub 2012 Oct 4. — View Citation
Terence L. Ahern, Andrew A. Herring, Bradley W. Frazee. Alameda County Medical Center - Highland Hospital, Oakland, CA Safety And Efficacy Of Low-dose Ketamine Infusion For Emergency Department Patients With Acute Severe Pain
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Overall Rate of Feeling Unreality | Overall rate of feeling of unreality as measured by Side Effects Rating Scale for Dissociative Anesthetics (SERSDA) | 30 minutes |
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