Clinical Trials Logo

Clinical Trial Summary

Pain is a common element of surgery. Opiates (morphine, oxycodone, hydrocodone, methadone, fentanyl) are very helpful in decreasing pain after surgery. Unfortunately, with repeated use opiates lose their effectiveness, such that patients need to utilize more opiates to achieve adequate pain relief - a phenomenon called tolerance. Sometimes tolerance to a pain reliever's effects can develop in just a few hours. It is thought that activation of the N-methyl d-aspartate (NMDA) receptor, a "switch" found on the surface of nerves, is partially responsible for opiate tolerance. Memantine is a medication that limits the activity of NMDA receptors in the brain and spinal cord. It has been used for years to help patients with Alzheimer's Disease. In this study, we will study the effects of memantine when combined with opiate medications to see whether it can increase the effectiveness of opiates for pain after surgery and reduce the side effects caused by opiates (e.g., sedation, nausea, itching).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT01041313
Study type Interventional
Source University of Washington
Contact Lydia Stout, BA
Phone 206-914-9253
Email lstout@uw.edu
Status Unknown status
Phase Phase 4
Start date January 2010
Completion date September 2011

See also
  Status Clinical Trial Phase
Completed NCT02284243 - Placebo-Controlled Evaluation of Intranasal Dexmedetomidine for Postoperative Analgesia Following Bunionectomy Surgery Phase 2
Completed NCT02720692 - Evaluation of N1539 Following Major Surgery Phase 3
Completed NCT03456141 - Multimodal Analgesic Protocol to Moderate Acute Pain
Terminated NCT02169336 - Placebo-Controlled Evaluation of Intranasal Dexmedetomidine for Postoperative Analgesia Following Bunionectomy Phase 2
Not yet recruiting NCT05950152 - Efficacy, Safety and Tolerability Study of Meloxicam Injection in Subjects After Abdominal Surgery Phase 2
Completed NCT02678286 - Evaluation of N1539 Following Abdominoplasty Surgery Phase 3
Completed NCT02675907 - Evaluation of N1539 Following Bunionectomy Surgery Phase 3
Completed NCT02540265 - Placebo-Controlled Evaluation of N1539 Following Bunionectomy Surgery Phase 2
Completed NCT03154658 - Serratus Anterior Plane Block in Patients Undergoing Mastectomy Phase 4