Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT00474773
Other study ID # GA3190YM
Secondary ID
Status Completed
Phase Phase 4
First received May 15, 2007
Last updated April 26, 2016
Start date June 2007
Est. completion date December 2009

Study information

Verified date January 2010
Source St. Louis Joint Replacement Institute
Contact n/a
Is FDA regulated No
Health authority United States: Institutional Review Board
Study type Observational

Clinical Trial Summary

This study will evaluate the benefits of continuing celecoxib through six weeks of total knee arthroplasty recovery. This is a randomized, double blind study with a group of approximately 130 primary total knee patients. All patients will receive celecoxib throughout their hospitalization as per current minimally invasive total knee arthroplasty protocol. At the time of hospital discharge, participating patients will be randomly placed on either celecoxib 200mg twice a day or a placebo twice a day.

This study will determine if the continued use of celecoxib for six weeks after total knee arthroplasty hospitalization will further decrease narcotic consumption, improve knee range of motion, improve ambulatory ability, and improve patient satisfaction over patients receiving celecoxib only during the acute hospitalization.


Recruitment information / eligibility

Status Completed
Enrollment 107
Est. completion date December 2009
Est. primary completion date December 2009
Accepts healthy volunteers
Gender Both
Age group N/A and older
Eligibility Inclusion Criteria:

- having undergone a minimally invasive total knee by select surgeon

- voluntarily enrolled

- independent community ambulators

- only patients being discharged directly home

Exclusion Criteria:

- celecoxib allergy or intolerence

- Renal insufficiency (defined as serum creatine level >1.5 mg/dL or BUN level >22mg/dL

- History of bleeding gastic or duodenal ulceration

- New York Heart Association Class III or IV Congestive Heart Failure

- Previous myocardial infarction or cerebralvascular event

- Severe inflammatory bowel disease

- Known coagulation abnormality or hepatic disease

- Chronic coumadin administration

- Refusal by primary or cardiac physician

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Related Conditions & MeSH terms


Intervention

Drug:
Celecoxib


Locations

Country Name City State
United States DePaul Health Center St. Louis Missouri

Sponsors (3)

Lead Sponsor Collaborator
St. Louis Joint Replacement Institute Biomet, Inc., Pfizer

Country where clinical trial is conducted

United States, 

See also
  Status Clinical Trial Phase
Completed NCT03334929 - Virtual Reality Distraction for Anxiety Reduction During Trigger Points Procedures in Pain Medicine Clinic N/A
Recruiting NCT06129383 - The Effect of Adding PIFP Block to SAP Block on Postoparative Pain Management in Patient Planned for Breast Surgery N/A
Completed NCT06054945 - Clinical Impact of IPACK Block Addition to Suprainguinal Fascia Iliaca Block
Active, not recruiting NCT02276495 - Can Single-Injection Adductor Canal Blocks Improve PostOp Pain Relief in Patients Undergoing Total Knee Arthroplasty? N/A
Completed NCT04094246 - Battlefield Acupuncture Following Shoulder Surgery N/A
Completed NCT05514236 - Effect of Virtual Reality and Music Therapy on Pain Relief in Outpatient Hysteroscopy N/A
Recruiting NCT04809935 - EUS-Coeliac Plexus Block Versus Radiofrequency Ablation in Pain Relief of Patients With Malignancy Phase 4
Not yet recruiting NCT05492903 - COMmunity of Practice And Safety Support for Navigating Pain (COMPASS-NP) N/A
Not yet recruiting NCT04328805 - Pain Reduction and Changes in Upper Limb Function Produced by an Ibuprofen Treatment in Carpal Tunnel Syndrome. Phase 4
Completed NCT02922101 - Evaluation of the Effectiveness of an Audit and Feedback Intervention With Quality Improvement Toolbox in Intensive Care N/A
Completed NCT01541293 - Intrauterine Lidocaine for Laminaria Phase 1
Not yet recruiting NCT01059487 - Bringing Acute and Wellness Care to Underserved Populations Using Traditional Chinese Medicine Phase 0
Completed NCT03290378 - Tramadol Versus Placebo in the Management of Postoperative Pain Following Bunionectomy Phase 3
Recruiting NCT05794828 - Erector Spinae Regional Anesthesia for Pain Control Early Phase 1
Active, not recruiting NCT04109885 - Paracervical Injection for Headache in the Emergency Department Phase 2
Recruiting NCT05857202 - Oxidative Stress and Inflammation Biomarkers in Surgically Treated Patients With Laryngeal Cancer
Recruiting NCT03851042 - Virtual Reality for Postoperative Pain After Laparoscopic Hysterectomy N/A
Completed NCT04566536 - NoL Monitor Performances of Nociceptive and Non-nociceptive Stimuli Discrimination During Robotic Surgery
Completed NCT03471390 - Improving Pain Management in Nursing Homes: a Pilot Study N/A
Enrolling by invitation NCT02995278 - Usage and Plan of Care Changes Due to Drug Screenings