Noninvasive Brain Stimulation for Pain Relief

Status Recruiting

Clinical Trial Summary

Non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial focused ultrasound (FUS), is be applied to healthy human subjects, acute pain patients, and chronic pain patients to investigate their uses for pain relief.

Clinical Trial Description

The research team will be using non-invasive brain stimulation techniques, transcranial magnetic stimulation (TMS) and transcranial focused ultrasound (FUS) to investigate their uses for pain relief in humans: healthy human subjects, acute pain patients, and chronic pain patients. Magnetic Resonance Imaging (MRI) and electroencephalogram (EEG) recordings will be collected to achieve the following objectives:

Objective 1 aims to determine the effects of noninvasive brain stimulation on the pain-related brain activities during pain processing. We hypothesize that noninvasive brain stimulation approaches will increase or decrease cortical activity upon processing painful input.

Objective 2 aims to determine the effects of noninvasive brain stimulation on pain intensity and/or pain-related behavioral assessments. We hypothesize that noninvasive brain stimulation will influence pain-intensity and/or pain-related behavioral assessments.

Objective 3 aims to investigate the correlation between brain activity and pain relief after noninvasive brain stimulation. We hypothesize that noninvasive brain stimulation will suppress cortical activity in pain-related brain areas, reduce pain intensity, and/or improve pain-related behavioral assessments. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04283643
Study type	Interventional
Source	University of Virginia
Contact
Status	Recruiting
Phase	N/A
Start date	April 1, 2019
Completion date	April 1, 2021

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05396820` - Adaptation of the Motor System to Experimental Pain	N/A
Completed	`NCT04356963` - Adjunct VR Pain Management in Acute Brain Injury	N/A
Recruiting	`NCT06350084` - Effect of Mother's Touch and Nurse's Therapeutic Touch on Pain Level and Crying Time During Heel Blood Collection	N/A
Completed	`NCT04080037` - Assessing Opioid Care Practices Using CPV Patient Simulation Modules	N/A
Recruiting	`NCT05458037` - RCT of Pain Perception With Fast and Slow Tenaculum Application	N/A
Completed	`NCT04571515` - Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain	Phase 2
Completed	`NCT06005480` - Understanding Rebound Pain After Regional Anesthesia Resolution in Healthy Volunteers	Phase 1
Active, not recruiting	`NCT04850079` - EHR Precision Drug Treatment in Neonates
Completed	`NCT03272139` - Interscalene Block Versus Superior Trunk Block	Phase 4
Completed	`NCT03271151` - Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty	Phase 4
Recruiting	`NCT05383820` - Effect of Paracetamol and Ketorolac on RANK-L Levels in Patients Starting Orthodontic Treatment	Phase 4
Completed	`NCT04851353` - Multiple Sensory Interventions On Infants' Pain and Physiological Distress During Neonatal Screening Procedures	N/A
Completed	`NCT03280017` - Ketamine With Multilevel Paravertebral Block for Post Video-assisted Thoracic Surgery Pain	Phase 4
Completed	`NCT04280796` - Changes in Affective Pain Processing in Human Volunteers	N/A
Not yet recruiting	`NCT04523623` - Pain Control Differences Between Oxycodone and Ibuprofen in Children With Isolated Forearm Injuries	N/A
Not yet recruiting	`NCT04491630` - COping With PAin Through Hypnosis, Mindfulness and Spirituality	N/A
Not yet recruiting	`NCT04062513` - Olfactive Stimulation Interventions With Mothers' Milk on Preterm Pain Response	N/A
Withdrawn	`NCT03137030` - A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of Different Amounts of Tablets of a New and a Marketed Tablet Formulation in Healthy Adults	Phase 1
Withdrawn	`NCT03137017` - A Comparison of Plasma Concentrations of Hydrocodone and Acetaminophen After Administration of a New and a Marketed Tablet Formulation Under Fasted and Fed Conditions in Healthy Adults	Phase 1
Completed	`NCT04659395` - How to Develop a Training Program for Nurses in Ultrasound Guided Femoral Nerve Block	N/A