Clinical Trials Logo

Clinical Trial Summary

The presented study is an experimental in-vitro study without intervention in-vivo. The effects of nitric oxide and prostacyclins, 5-hydroxymethylfurfural and alpha-ketoglutarate, volatile anaesthetics on haemoglobin oxygen (HbO2) affinity will be investigated in-vitro. Venous blood samples of 20 healthy young volunteers (10 female, 10 male) will be collected twice in the period of one week. Informed consent will be given. Every blood collection will be accompanied by a venous blood gas analysis. The blood samples will be transferred to the laboratory for in-vitro recording of the complete oxygen dissociation curve (ODC). A newly developed in-vitro method will be used. On the first study day the blood samples will be exposed to three different concentrations of nitric oxide during the measurement, followed by two different vapourized prostacyclins. In addition, different concentrations of 5-hydroxymethylfurfural and alpha-ketoglutarate will be given to the blood samples for ODC recording. On the second study day the dose dependent effects of three different volatile anaesthetics will be investigated by exposing the blood samples to these drug while the measurements. Following these ODC recordings, aliquots of the blood samples will be frozen and investigated for storage related changes in HbO2 affinity.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04612270
Study type Interventional
Source Medical University Innsbruck
Contact
Status Completed
Phase N/A
Start date November 4, 2020
Completion date June 1, 2021

See also
  Status Clinical Trial Phase
Completed NCT04597983 - Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists N/A
Recruiting NCT05858463 - High Intensity Interval Training and Muscle Adaptations During PR N/A
Completed NCT03331471 - Alveolar Recruitment Maneuver During Pneumoperitoneum N/A
Completed NCT04626453 - Oxygenation Changes After 2-month Exercise in Sedentary Older Adults With Diabetes N/A
Enrolling by invitation NCT04322994 - THRIVE Use in Pediatric Populations- Multi Site N/A
Not yet recruiting NCT05578131 - High-flow Nasal Cannula for Pediatric Anesthetic Induction N/A
Completed NCT05677009 - Sustainable Preservation of Essential Oxygen Resources: A Phase 4 Crossover Study of the BUFEO System: SAVE O2 N/A
Completed NCT04584788 - Validation of the O3 Regional Somatic Tissue Oxygenation Monitor N/A
Recruiting NCT04141956 - Incidence of Use of High-Flow Nasal Cannula Oxygen Therapy in Intensive Care Units Patients
Completed NCT04973046 - Tissue Oxygen Saturation for Esophagectomy
Terminated NCT03665259 - Lower Inspiratory Oxygen Fraction for Preoxygenation N/A
Recruiting NCT03396172 - FreeDom: Innovative Strategy for the Management of COPD Exacerbations N/A
Completed NCT03128372 - Validation of Next Generation Cerebral and Tissue Oximeter N/A
Completed NCT05430724 - The Effects of Nicardipine and Esmolol Applied for Controlled Hypotension N/A
Recruiting NCT05783050 - Wei Nasal Jet Tube vs Nasal Cannula Oxygen Support in Gastrointestinal Endoscopy Patients N/A
Completed NCT04711317 - Pre-oxygenation With High-flow Nasal Cannula in Caesarian Section Under General Anesthesia N/A
Completed NCT03185507 - The Effect of Cryotherapy on Cerebral Hemodynamics Within Healthy Subjects Phase 1
Completed NCT04266665 - Effect of Dexmedetomidine on Brain Homeostasis and Neurocognitive Outcome Phase 4
Completed NCT06371651 - Creatine and GAA for Brain Oxygenation N/A
Completed NCT05866289 - Awake Prone Positioning for COVID-19 Acute Hypoxaemic Respiratory Failure