Effect of HEPA Air Filters on Subclinical Markers of Cardiovascular Health

Oxidative Stress Clinical Trial

— WEST  

Official title:

Assessing the Impact of Wood Stove Interventions on Air Quality

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01256957
• Other study ID #: 869329
• Status: Completed
• Phase: N/A
• First received: December 8, 2010
• Last updated: December 1, 2016
• Start date: November 2008
• Est. completion date: April 2009

Study information

• Verified date: December 2010
• Source: Simon Fraser University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Canada: Ethics Review Committee
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to evaluate the ability of portable high efficiency particle air (HEPA) filters to reduce exposures to PM2.5 and woodsmoke air pollution indoors and to improve subclinical indicators of microvascular function, systemic inflammation, and oxidative stress among healthy adult participants.

Description:

The investigators will use portable HEPA filters in a single-blind randomized crossover design. Each participant's home will be monitored for two consecutive seven-day periods, during which time two HEPA units (one in the bedroom and one in the main living room) will be operated indoors. During one 7-day period the HEPA filters will be operated normally, and during the other period the HEPA unit will be operated without the internal filter in place (i.e., "placebo filtration"), thus blinding participants to the filters' status. The order of filtration or non-filtration will be random. At the end of each 7-day period microvascular function will be assessed, blood will be collected for assessment of systemic inflammatory markers, and urine will be collected for assessment of oxidative stress markers.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 56
• Est. completion date: April 2009
• Est. primary completion date: April 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 19 Years and older

Eligibility

Inclusion Criteria:

• 19 years or older

• Non-smoking household

• Lives in study region (Smithers or Telkwa British Columbia)

Exclusion Criteria:

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Endothelial Function
• Inflammation
• Oxidative Stress
• Systemic Inflammation

Intervention

Device:
• HEPA filter

Locations

Country	Name	City	State
Canada	Simon Fraser University	Burnaby	British Columbia

Sponsors (4)

Lead Sponsor	Collaborator
Simon Fraser University	Health Canada, Ministry of Environment, British Columbia, University of British Columbia

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Reactive hyperemia index		After 1 week of air filtration	No
Secondary	C-reactive protein		After 1 week of filtration	No