Lithia Water Study: Effects of Lithia Water on BDNF & Oxidative Stress

Status Terminated

Clinical Trial Summary

This study investigates the effects of daily use of lithia water on blood tests of neuronal oxidative stress, mood, and well-being. Lithia water is a type of pure spring water containing trace levels of lithium, which is a naturally occurring mineral. Neuronal oxidative stress is caused by normal chemical reactions in the human body that sometimes result in damage to brain cells. Participation in this study will last for 8 weeks and includes daily use of study water for drinking.

The primary objective of this pilot study is to test the hypothesis that, in healthy male participants, daily use of lithia water will improve neurogenesis and antioxidant capacity as measured by serum levels of brain-derived neurotrophic factor (BDNF) and oxidative stress markers. Secondary objectives will include examining self-reported changes in mood, cognition, and well-being.

Clinical Trial Description

There is some indication from epidemiological studies that areas with trace concentrations of lithium in drinking water have lower rates of suicide. This study will evaluate the effects of drinking EDJ (pronounced "edge") lithia spring water (which comes from a natural spring in the Rocky Mountains and contains trace amounts [0.68 mg/litre] of lithium) for 4 weeks, compared to drinking commercially available bottled water (which contains no lithium at all) for 4 weeks.

This pilot study has been designed as an 8-week randomized, counterbalanced, crossover study in 15 healthy male participants. Eligible participants will use lithia water or control water for daily ingestion for 4 weeks, then cross over to the other condition for another 4 weeks. At baseline and after each 4-week condition, participants will complete self-report questionnaires of mood, cognition and well-being, and blood samples will be assayed for BDNF and oxidative stress protein markers. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)

Related Conditions & MeSH terms

Oxidative Stress

Clinical Trial Details

NCT number	NCT01257867
Study type	Interventional
Source	University of British Columbia
Contact
Status	Terminated
Phase	N/A
Start date	March 2011
Completion date	October 2012

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT03255187` - Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution	N/A
Completed	`NCT04136821` - The Long-term Effects of Oceanix™ on Resistance Training Adaptations	N/A
Recruiting	`NCT03790345` - Vitamin B6 and B12 in the Treatment of Movement Disorders Induced by Antipsychotics	Phase 2/Phase 3
Completed	`NCT03358524` - Effects of Vitamin E Supplementation on Free Radicals and Fat Level of Obese Adolescence in Jakarta, Indonesia	Phase 4
Recruiting	`NCT05327348` - Effectiveness of IV Vitamin C in Reducing Oxidative Stress Associated With Free Flap Surgery	Phase 3
Completed	`NCT03288623` - The Effects of Dark Chocolate Implementation in Elite Athletes	N/A
Completed	`NCT04419025` - Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease	Phase 2
Completed	`NCT04597983` - Effect of 8-week Intake of 2S-hesperidin on Performance, Body Composition and Biochemicals Markers in Amateur Cyclists	N/A
Not yet recruiting	`NCT06159543` - The Effects of Fresh Mango Consumption on Cardiometabolic Outcomes in Free-living Individuals With Prediabetes	N/A
Enrolling by invitation	`NCT03030456` - Whole Body Vibrations on Functional Capacity, Muscular Strength, and Biochemical Profile in Elders	N/A
Completed	`NCT02256254` - SIMOX - Induction of Oxidative Stress	Phase 2
Not yet recruiting	`NCT02202239` - Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients	Phase 4
Recruiting	`NCT02048592` - Impact of Immunonutrition on the Patients With Cystic Fibrosis	Phase 4
Completed	`NCT01942460` - Ferumoxytol for Iron-Deficiency Anemia in Chronic Kidney Disease and Peritoneal Dialysis Patients	Phase 4
Completed	`NCT02463318` - The Effect of Melatonin on Gene Expression and Activity of the Sirt1 and Its Target Genes Catalase and MnSOD in Multiple Sclerosis Patients and Healthy Subjects	N/A
Completed	`NCT01990391` - Brazil Nut Consumption in Microvascular Endothelial Function, Oxidative Stress and Metabolic Abnormalities	N/A
Completed	`NCT02177383` - Action of Essential Fatty Acids on the Expression of Antioxidant Genes and Athletic Performance	N/A
Completed	`NCT00845130` - Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes	N/A
Completed	`NCT00607893` - Efficacy of Continuous Positive Airway Pressure in Reducing Oxidative Stress in Individuals With Sleep Apnea	N/A
Active, not recruiting	`NCT00247507` - The Effects of Acetylcysteine on Alleviating Damage of Oxidative Stress in Hemodialysis Patients	Phase 4

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Lithia Water Study: Effects of Lithia Water on BDNF and Oxidative Stress Markers in Healthy Male Participants

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms