Overweight Clinical Trial
Official title:
Prevention of Frailty in Breast Cancer Survivors: A Pilot Study
This trial studies how well weight bearing exercise works in preventing frailty in stage I-IIIA breast cancer survivors. Weight bearing exercise, including muscle-strengthening, aerobic, flexibility, and balance exercises, can decrease fat and increase muscle, which may lead to reduced frailty.
PRIMARY OBJECTIVES:
I. Demonstrate reproducibility of forearm muscle activation and subcutaneous fat measures in
a healthy convenience sample/population (N= 10).
II. Demonstrate that measures of muscle activation and signal attenuation by subcutaneous fat
mass can be conducted in a systematic and reproducible fashion in breast cancer survivors
prior to and following weight bearing exercise training.
III. In a cross sectional analysis, describe the level of lean muscle mass, muscle
activation, strength, insulin resistance, inflammatory cytokines and growth factors, and
inter-individual variability in breast cancer survivors prior to training.
IV. Describe the level of lean muscle mass, muscle activation, strength, insulin resistance,
inflammatory cytokines (such as IL-6, CRP and others), and growth factors (such as myostatin,
IGF-1, IGFBP-3 and others) in breast cancer survivors following weight bearing exercise
training.
V. Evaluate the influence of genetic variability on response to prescribed training in breast
cancer survivors.
OUTLINE:
Participants undergo a weight bearing exercise program in a group 2 days a week and at home 5
days a week for 8 weeks.
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