Overweight Clinical Trial
Official title:
Cholinergic Status and the Metabolic Syndrome
The investigators aims in the current study are to examine whether the cholinergic status should be considered as another risk factor for the metabolic syndrome and it's co-morbidities and to test the effect of a hypocaloric high complex carbohydrates diet on the cholinergic status of overweight and obese adults with and without the metabolic syndrome.
Intervention studies have demonstrated that the autonomic disturbances of the metabolic
syndrome may be reversible. A reduction in body weight induced by a hypocaloric diet exerts
a marked reduction in sympathetic activity in obese people with or without metabolic
syndrome. Incorporation of regular, moderate intensity aerobic exercise training during a
dietary weight loss program does not confer additional benefits on resting sympathetic
neural activity, compared with weight loss by diet alone. A new method has been developed to
examine the sympathetic-parasympathetic status of an individual - the cholinergic status.
Cholinergic Status represents the total soluble circulation capacity for acetylcholine
hydrolysis. Higher cholinergic status means the individual is more sympathetic .
A cross sectional study that took place in Tel Aviv Sorasky medical center and included 632
participants found that the cholinergic status is related to metabolic syndrome parameters
in a dose response manner and that it correlates significantly with glucose,HbA1c, lipid
profile and hs-CRP.
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Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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