Overweight Clinical Trial
Official title:
The Effect of Acute and Short-term Intervention With Fish Oil on Overweight Subjects - Focus on Inflammation
The aim of this study is to investigate the effects of acute and short-term intervention with fish oil on inflammatory markers in overweight subjects.
Being overweight is associated with metabolic syndrome, cardiovascular disease, and diabetes
mellitus (type 2). Adipose tissue can be regarded as an active organ, which produces an
array of inflammatory mediators. This creates a state of chronic low-grade inflammation.
Inflammation has been proven to be a key element in the development of atherosclerotic
plaques.
The marine n-3 polyunsaturated fatty acids (PUFAs) have beneficial effects on cardiovascular
disease. These effects are partly attributed to the anti-inflammatory effect of the n-3
PUFAs.
Previous studies have shown an anti-inflammatory effect of n-3 PUFAs in overweight subjects,
but the studies have been conducted with a high daily dose of n-3 PUFA. We want to examine
the effect of a lower dose of 1 g n-3 PUFA/day (the dose recommended by the Danish Heart
Foundation).
The study is randomized, placebo-controlled and double blinded. Fifty subjects aged 30 - 75
years (postmenopausal women; waist circumference > 80 cm and men; waist circumference > 94
cm) will be included.
Blood samples and fatty tissue biopsies will be collected at baseline, after 1 day and after
6 weeks.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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