Overweight Clinical Trial
Official title:
Effects of (1,3), (1,6)-Beta-D-glucan on Insulin Sensitivity and Inflammatory Markers of the Metabolic Syndrome
Insoluble (1,3),(1,6)-beta-D-glucan from bakers yeast are indigestible polysaccharides.
Previous studies indicate that the intake of insoluble dietary fiber is strongly associated
with reduced risk of type 2 diabetes and cardiovascular disease. However, the mechanisms
leading to this phenomenon are largely unknown.
There are close relations between metabolic and inflammatory pathways, and a number of
hormones, cytokines, signal proteins, bioactive lipids, and transcription factors have been
shown to be involved in both systems.
Beta-D-glucans have been suggested to play a role as so called biological response
modifiers. Studies in animals indicate that even small doses of (1,3),(1,6)-beta-D-glucan
may have beneficial effects on immune activity, i.e., by reducing the secretion of
inflammatory factors.
The investigators hypothesize that the intake of isolated (1,3), (1,6)-beta-D-glucan from
bakers yeast improves inflammatory makers and insulin-sensitivity in overweight subjects
with increased C-reactive protein concentrations at baseline.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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