Overweight Clinical Trial
Official title:
The Effect of Modified Sham Feeding With Orlistat in Overweight and Obese Subjects: A Pilot Study
The purpose of this study is to determine if the drug orlistat (Alli, Xenical) decreases the taste for fat in humans.
One screening visit and Testing Visits 1 and 2: Approximately 1-2 hours (Fasting - You will
have nothing to eat or drink (except water or medications) after midnight before the test
visit.) If you qualify for the study, you will return to Pennington Biomedical Research
Center for the test visit
- You will be given a questionnaire to screen for allergies or cold symptoms.
- Women will answer a questionnaire based on their menstrual cycle.
- Before eating, you will be given instructions on how to use the study medication. You
will swish about 2 teaspoons of a solution in your mouth for 30 seconds and then spit
it out (like mouthwash).
- Just before eating, you will be given another brief questionnaire judging your
appetite.
- You will be given the test meal. You will be allowed to eat as much or as little as you
like during a 20-minute eating period.
- 30 minutes after starting your meal you will be given the brief questionnaire again to
judge your appetite.
- You will return in 1 month to complete test visit 2.
;
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
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