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Efficacy and Safety of Apitegromab for the Treatment of Adults Who Are Overweight or Obese — EMBRAZE  

Overweight and Obesity Clinical Trial

Official title:
A Phase 2 Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Apitegromab in Overweight and Obese Adult Subjects

Clinical Trial Summary

A phase 2 study to evaluate the effects of apitegromab as an adjunctive therapy to GLP-1 agonist therapy in subjects with overweight or obesity

Clinical Trial Description

This phase 2 randomized, double-blind, placebo-controlled, multicenter study will assess the safety, efficacy, and pharmacokinetics (PK) of apitegromab when used as an adjunctive therapy to GLP-1 agonist therapy in subjects with overweight and obesity and without diabetes. Each subject will receive either semaglutide or tirzepatide, depending upon availability, and will maintain that course throughout the treatment period. In addition, all subjects will be randomized 1:1 to receive either apitegromab or placebo during the treatment period. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06445075
Study type Interventional
Source Scholar Rock, Inc.
Contact Scholar Rock, Inc. Clinical Trials Administration
Phone 857-259-3860
Email clinicaltrials@scholarrock.com
Status Recruiting
Phase Phase 2
Start date May 21, 2024
Completion date October 20, 2025
View Details
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