Overall Survival Clinical Trial
Official title:
A Retrospective Study of Extremity Osteosarcoma Patients Who Recieved Intra-arterial Limb Infusion of Cisplatin During Neoadjuvant Chemotherapy
Verified date | January 2021 |
Source | Peking University People's Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Although there seems to be no benefit from improving the histologic response rate or long-term survival of intra-arterial infusion of cisplatin for localized osteosarcoma of extremities with IOR/OS-3, IOR/OS-5, and COSS 86 protocols, such a treatment strategy is still believed to potentially increase the tumoricidal effect with an increase in higher local concentrations of the infused agents combined with longer tissue exposure time. Besides, the relationship of chemotherapy-induced necrosis and surgical margins is still the main concern for localized osteosarcoma patients to achieve long-term survival. The investigators intend to analyze the gain and loss from transcatheter intra-arterial limb infusion of cisplatin for extremity osteosarcoma in the past six years.
Status | Completed |
Enrollment | 99 |
Est. completion date | April 8, 2019 |
Est. primary completion date | April 1, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility | Inclusion Criteria: - histological diagnosis of high-grade osteosarcoma - located at extremities - following the PKUPH-OS protocol - accept to recieve IA or IV infusion of cisplatin Exclusion Criteria: - lost to follow-up - did not recieve definitve surgery in Musculoskeletal Tumor Center of Peking University People's Hospital - quiting to recieve chemotherapy |
Country | Name | City | State |
---|---|---|---|
China | Peking University People's Hospital | Beijing | Beijing |
Lead Sponsor | Collaborator |
---|---|
Peking University People's Hospital |
China,
Xie L, Xu J, Dong S, Gao J, Tang X, Yan T, Yang R, Guo W. Gain and loss from transcatheter intra-arterial limb infusion of cisplatin for extremity osteosarcoma: a retrospective study of 99 cases in the past six years. Cancer Manag Res. 2019 Jul 30;11:7183 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | event-free survival, EFS | We calculated EFS from the date of diagnosis to the last follow-up, local recurrence, distant metastasis, or death. | 5 years | |
Primary | overall survival, OS | We calculated OS from the date of diagnosis to the last follow-up or death. | 5 years | |
Secondary | pathological response | We calculated the tumor response rates in different groups as the percentage of patients who had a tumor necrosis rate of more than 90%. | 2 years | |
Secondary | recurrence-free survival | We defined recurrence-free survival from the time of surgery to the date of local recurrence. | 5 years |
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