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Ovarian Failure clinical trials

View clinical trials related to Ovarian Failure.

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NCT ID: NCT06426771 Not yet recruiting - Clinical trials for Polycystic Ovary Syndrome

Effect of Antimullerian Hormone Levels on the Inflammatory Index, Phytochemical Index and NRF Nutrient Density

AMH
Start date: June 1, 2024
Phase:
Study type: Observational [Patient Registry]

The aim of the study was to calculate the dietary inflammatory index, dietary phytochemical index and NRF nutrient density of the dietary pattern routinely consumed by women and to assess whether there is a difference between PCOS patients with high AMH levels and the group with low AMH levels.

NCT ID: NCT06394466 Completed - Thyroid Diseases Clinical Trials

Thyroid Function and Autoimmunity in Subfertility Women and Assisted Reproductive Therapy

Start date: July 1, 2021
Phase:
Study type: Observational [Patient Registry]

The assessment of ovarian reserve is well established based on the dosage of anti-Mullerian hormone (AMH). The clinical applicability of detecting thyroid autoantibodies levels has been discussed as a potential marker of low-grade inflammation. There are no studies about the detection of these autoantibodies in infertile women. Our objective is to evaluate the association between ovarian reserve and thyroid function and its autoimmunity in infertile women seeking for assisted reproductive treatment (ART).Evaluation ot thyroid function in the first trimester in also be evaluated in women submitted to ART.

NCT ID: NCT05443282 Completed - Oxidative Stress Clinical Trials

Ovarian Reserve and Matrix Metalloproteinases

Start date: August 10, 2021
Phase:
Study type: Observational

Primary Ovarian Insufficiency (POI) is dysfunction of ovaries before 40 years of age. It has been reported that genetic factors, endocrine disorders, previous pelvic surgeries, chemotherapy and radiotherapy, and autoimmune mechanisms play a role in 10%, however the etiology has not been clarified in 90% of the cases. Oxidative stress and autoimmunity has been shown to be responsible in the etiopathogenesis of POI. Prolidase is an imidodipeptidase. Prolidase was shown to be related with oxidative stress and autoimmune diseases in previous studies. In addition, it is thought that the level of prolidase plays a role both in the etiopathogenesis and progression of diseases. This study aims to investigate the level of prolidase enzyme in women with POI.

NCT ID: NCT05181748 Recruiting - Infertility, Female Clinical Trials

Autologous Platelet Rich Plasma Intraovarian Infusion for Poor Responders

PRPPOR
Start date: January 23, 2019
Phase: Phase 2/Phase 3
Study type: Interventional

Autologous platelet rich plasma (PRP) intraovarian infusion may improve ovarian response to controlled ovarian stimulation as well as the hormonal profile of poor ovarian response infertile women subjected to intracytoplasmic sperm injection (ICSI) treatment.

NCT ID: NCT05158933 Recruiting - Ovarian Failure Clinical Trials

Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Ovarian Failure

Start date: December 2022
Phase: Phase 1
Study type: Interventional

This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord derived mesenchymal stem cells for the treatment of Ovarian Failure

NCT ID: NCT04776902 Completed - Ovarian Failure Clinical Trials

Effects of Ovarian Reserve on Sexual Satisfaction

EROSS
Start date: October 1, 2020
Phase: N/A
Study type: Interventional

This is a survey study. The primary aim of the study is to investigate the relationship between the ovarian reserve and sexual satisfaction. All the patients who underwent ovarian reserve assessment for any reason will fill a questionnaire about sexual satisfaction. And the survey results will be compared with patients' ovarian reserve.

NCT ID: NCT04444245 Active, not recruiting - Hormone Disturbance Clinical Trials

Ovarian Rejuvenation Using Platelet Rich Plasma (PRP) & Autologous Tissue Stromal Vascular Fraction (tSVF) and Cell Enriched tSVF

OVAR-REJUV
Start date: July 15, 2022
Phase: Phase 1
Study type: Interventional

Trial of imaging guided intra-ovarian injection to improve ovarian function in clinical settings of Premature Ovarian Failure, Perimenopausal and /or early postmenopausal symptomatology and related hormonal deficiencies. The study will compare the effectiveness of autologous Platelet Rich Plasma alone versus Stromal Vascular Fraction (tSVF and/or cellular stromal vascular fraction (cSVF) in combination with Platelet Rich Plasma as regards efficacy and duration of ovarian reactivation in women with acquired Premature Ovarian Failure, Menopausal, and Perimenopausal women.

NCT ID: NCT04306185 Not yet recruiting - IVF Clinical Trials

Ovarian Fragmentation Study (Crespo Medical Team)

Start date: May 1, 2020
Phase: N/A
Study type: Interventional

This is a study designed to validate Kawamura´s theory and investigation of activation of primordial follicles through ovarian cortex fragmentation. Our aim is to evaluate embryo quality following this procedure in poor ovarian responders and patients with decreased ovarian reserve. Secondary objectives are to assess potential association with the number of oocytes retrieved and pregnancy rates after IVF.

NCT ID: NCT04275700 Recruiting - Clinical trials for Diminished Ovarian Reserve

Study of PRP in Women With Evidence of Diminished Ovarian Reserve

PRP4AGE
Start date: October 1, 2018
Phase: N/A
Study type: Interventional

The hypothesis of the study is that ovaries of women with a history of poor response to ovulation induction may benefit from exposure to growth factors known to be present in Platelet Rich Plasma (PRP). Since even ovaries from women with poor response still contain primordial follicles (which, however, no longer undergo recruitment), it is hoped that PRP injections into ovaries will activate follicular recruitment pathways and, subsequently, result in follicle growth. Should such growth be observed, follicles will be supported with routine daily gonadotropin stimulation until hCG trigger.

NCT ID: NCT04163640 Completed - Infertility, Female Clinical Trials

Ovarian Rejuvenation for Premature Ovarian Insufficiency and Poor Ovarian Response

Start date: February 24, 2020
Phase: N/A
Study type: Interventional

The objective of this study is to perform a prospective randomized controlled trial seeking to characterize the effects of intra-ovarian injection of platelet rich plasma (PRP) on biomarkers of ovarian reserve as well as IVF outcomes in women with primary ovarian insufficiency (POI) and poor ovarian response (POR) who decline the use of an egg donor to establish a pregnancy.