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Clinical Trial Summary

Gavocabtagene autoleucel (gavo-cel; TC-210) is a novel cell therapy that consists of autologous genetically engineered T cells expressing a single-domain antibody that recognizes human Mesothelin, fused to the CD3-epsilon subunit which, upon expression, is incorporated into the endogenous T cell receptor (TCR) complex. This Phase 1/2 study aims to establish the recommended Phase 2 dose (RP2D) and subsequently evaluate the efficacy of gavo-cel, with and without immuno-oncology agents, in patients with advanced mesothelin-expressing cancers, with overall response rate and disease control rate as the primary Phase 2 endpoints.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03907852
Study type Interventional
Source TCR2 Therapeutics
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date April 15, 2019
Completion date November 2, 2028

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