Acute Respiratory Distress Syndrome Clinical Trial
— PIONEEROfficial title:
Predicting Length of Mechanical Ventilation in Moderate-to-severe Acute Respiratory Distress Syndrome Using Machine Learning
Verified date | February 2024 |
Source | Dr. Negrin University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
The investigators are planning to perform a secondary analysis of an academic dataset of 1,303 patients with moderate-to-severe acute respiratory distress syndrome (ARDS) included in several published cohorts (NCT00736892, NCT022288949, NCT02836444, NCT03145974), aimed to characterize the best early scenario during the first three days of diagnosis to predict duration of mechanical ventilation in the intensive care unit (ICU) using supervised machine learning (ML) approaches.
Status | Completed |
Enrollment | 1303 |
Est. completion date | February 2, 2024 |
Est. primary completion date | February 2, 2024 |
Accepts healthy volunteers | |
Gender | All |
Age group | 18 Years to 100 Years |
Eligibility | Inclusion Criteria: - Berlin criteria for moderate to severe acute respiratory distress syndrome Exclusion Criteria: - Postoperative patients ventilated <24h - brain death patients |
Country | Name | City | State |
---|---|---|---|
Spain | Complejo Hospitalario de Albacete | Albacete | |
Spain | Complejo Hospitalario Universitario de Albacete (ICU) | Albacete | |
Spain | Department of Anesthesia, Hospital Clinic | Barcelona | |
Spain | Hospital General de Ciudad Real (ICU) | Ciudad Real | |
Spain | Hospital Virgen de La Luz | Cuenca | |
Spain | Hospital Universitario de A Coruña (ICU) | La Coruña | |
Spain | Hospital Universitario Dr. Negrin | Las Palmas De Gran Canaria | Las Palmas |
Spain | Complejo Hospitalario Universitario de León | León | |
Spain | Hospital Fundación Jiménez Díaz | Madrid | |
Spain | Hospital Universitario La Paz (ICU) | Madrid | |
Spain | Hospital Universitario Ramón y Cajal (Anesthesia) | Madrid | |
Spain | Hospital Universitario Puerta de Hierro (ICU) | Majadahonda | Madrid |
Spain | Hospital Universitario Carlos Haya | Málaga | |
Spain | Hospital Universitario Regional de Malaga Carlos Haya (ICU) | Málaga | |
Spain | Hospital Universitario Virgen de Arrixaca (ICU) | Murcia | |
Spain | Hospital Universitario NS de Candelaria | Santa Cruz de Tenerife | Tenerife |
Spain | Hospital NS del Prado | Talavera de la Reina | Toledo |
Spain | Hospital Universitario Río Hortega (ICU) | Valladolid | |
Spain | Hospital Virgen de la Concha (ICU) | Zamora | |
United Kingdom | Cardiff University | Cardiff |
Lead Sponsor | Collaborator |
---|---|
Dr. Negrin University Hospital | Cardiff University, Leiden University Medical Center, Unity Health Toronto |
Spain, United Kingdom,
Figueroa-Casas JB, Dwivedi AK, Connery SM, Quansah R, Ellerbrook L, Galvis J. Predictive models of prolonged mechanical ventilation yield moderate accuracy. J Crit Care. 2015 Jun;30(3):502-5. doi: 10.1016/j.jcrc.2015.01.020. Epub 2015 Jan 30. — View Citation
Villar J, Ambros A, Mosteiro F, Martinez D, Fernandez L, Ferrando C, Carriedo D, Soler JA, Parrilla D, Hernandez M, Andaluz-Ojeda D, Anon JM, Vidal A, Gonzalez-Higueras E, Martin-Rodriguez C, Diaz-Lamas AM, Blanco J, Belda J, Diaz-Dominguez FJ, Rico-Feijo — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Days on mechanical ventilation | Duration of mechanical ventilation | from diagnosis to extubation | |
Secondary | ICU mortality | mortality in the intensive care unit | up to 24 weeks |
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