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NCT05988671 Clinical Trial

Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Postoperative Nausea and Vomiting Clinical Trial

Official title:
Comparison of Intraperitoneal Dexamethasone, Dexmedetomidine, and Dexamethasone-Dexmedetomidine Combination on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy: A Randomized Clinical Trial

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05988671
Other study ID # RC 10-3-2023
Secondary ID
Status Recruiting
Phase Phase 3
First received
Last updated
Start date August 10, 2023
Est. completion date March 30, 2024

Study information
Verified date February 2024
Source Al-Azhar University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Nausea and vomiting are some of the most common complaints of patients after any anesthesia, which is often associated with postop-erative pain. The double-blind clinical trial study aimed to compare the prophylactic effect of dexamethasone and dexmedetomidine and their combination in reducing postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.

Recruitment information / eligibility
Status Recruiting
Enrollment 120
Est. completion date March 30, 2024
Est. primary completion date March 30, 2024
Accepts healthy volunteers No
Gender All
Age group 20 Years to 50 Years
Eligibility Inclusion Criteria: - Patients aged from 20 - 50 years - ASA I OR II - undergo laparoscopic cholecystectomy Exclusion Criteria: - Patients with history of psychotic illnesses, - Parkinson's disease - motion disorder - Smoker - or history of chemotherapy

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• normal Saline
Intraperitoneal route
• Dexamethasone
Intraperitoneal route
• Dexmedetomidine
Intraperitoneal route
• Combination of dexamethasone + dexmedetomidine
Intraperitoneal route

Locations
Country Name City State
Egypt Haney Baumey Banha
Egypt Neveen Kohaf Tanta

Sponsors (2)
Lead Sponsor Collaborator
Al-Azhar University Benha University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary The number of patients suffered from postoperative nausea and vomiting will be recorded in each group. 24 hours postoperative
Secondary antiemetic consumption frequency of antiemetic consumption will be determined 24 hours postoperatively
See also
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Unknown status NCT01268748 - Single Port Versus Four Ports Laparoscopic Cholecystectomy and Early Postoperative Pain N/A
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