Microbiological Profile of VAP Patients in Respiratory ICU

VAP - Ventilator Associated Pneumonia Clinical Trial

— VAP  

Official title:

Microbiological Profile of Ventilator Associated Pneumonia in Respiratory Intensive Care Unit of Assiut University Hospital

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05738928
• Other study ID #: Microbiological profile of VAP
• Status: Not yet recruiting
• Start date: February 2023
• Est. completion date: February 2024

Study information

• Verified date: February 2023
• Source: Assiut University
• Contact: Manar A Hassan, bacheoler
• Phone: +201152808012
• Email: manarabdelhameed89[@]yahoo.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Identification of the microbial profile of Ventilator associated pneumonia causing microorganisms among Respiratory ICU patients .

Description:

Ventilator-associated pneumonia (VAP) is one of the common serious infectious diseases encountered in the intensive care unit (ICU), which highly affects the healthcare cost and patient prognosis.

All-cause of mortality associated with VAP has been reported to range from 20% to 50%.

The etiology of VAP and their antimicrobial susceptibility pattern varies with different patient populations and types of ICUs.

VAP may be caused by a wide spectrum of bacterial pathogens, which may be polymicrobial and are rarely due to viral or fungal pathogens in immune-competent hosts.

Common etiologic agents are Gram-negative bacilli such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter spp. and Staphylococcus aureus among Gram-positive cocci.

Due to the increased incidence of MDR organisms in Intensive Care Units (ICUs), early and correct diagnosis of VAP is mandatory for optimal antibiotic therapy. The frequency of specific MDR pathogens causing VAP varies in hospitals, patient populations. Also varies according underlying disease.

this study will be conducted in respiratory intensive care unit, chest disease and tuberculosis department at Assiut university hospitals.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 86
• Est. completion date: February 2024
• Est. primary completion date: December 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

1. Mechanically ventilated patient who developed pneumonia after48 hours after endotracheal intubation.

2. Age > 18 years.

Exclusion Criteria:

1. Patients with clinical and radiological signs suggestive of pneumonia before intubation (community acquired pneumonia or hospital acquired pneumonia)

2. Patients age =18 years old

Related Conditions & MeSH terms

• Pneumonia
• Pneumonia, Ventilator-Associated
• VAP - Ventilator Associated Pneumonia

Intervention

Diagnostic Test:
• blood and sputum culture
Noninvasive sampling ( Endo Tracheal Aspiration) for staining and culture. Blood culture .

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Microbiological profile of ventilator associated pneumonia in Respiratory ICU in Assiut University Hospital.	Identify the microbial profile of VAP causing microorganisms among ICU patients, antimicrobial susceptibility patterns among the frequently isolated organisms and resistant strains.	1 year