Study to Evaluate R3R01 in Patients With Alport Syndrome and Patients With Focal Segmental Glomerulosclerosis

Focal Segmental Glomerulosclerosis Clinical Trial

Official title:

A Phase II, Multi-center, Open-Label Study to Assess Safety, Tolerability, Efficacy and Pharmacokinetics of R3R01 in AS Patients With Uncontrolled Proteinuria on ACE/ARB Inhibition and in Patients With Primary Steroid-Resistant FSGC

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05267262
• Other study ID #: R3R01-ASFSGS-201
• Status: Recruiting
• Phase: Phase 2
• Start date: June 15, 2022
• Est. completion date: June 2, 2025

Study information

• Verified date: February 2024
• Source: River 3 Renal Corp.
• Contact: Kathie Gabriel, RN, MFT
• Phone: 610-937-1932
• Email: kgabriel[@]narrowrivermgmt.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This is a Phase 2, Multi-center, Open-Label Study to Assess Safety, Tolerability, Efficacy and Pharmacokinetics of R3R01 in Alport Syndrome Patients with Uncontrolled Proteinuria on ACE/ARB Inhibition and in Patients with Primary Steroid-Resistant Focal Segmental Glomerulosclerosis

Description:

R3R01 is investigational small molecule designed to decrease fat levels in certain cells in the kidney and therefore may improve kidney function and reduce damage in the kidney. This is a single arm open-label study enrolling patients in three cohorts. Cohort 1 will include 5 adult (≥18 y/o) patients from Cohorts 2 and 3 (including at least one patient from Cohort 2 and at least one patient from Cohort 3). Cohort 2 will include approximately 20 male and female patients from 12 years and older with X-linked Alport Syndrome (AS), and male and female patients with autosomal inherited AS. Cohort 3 will include approximately 30 male and female patients from age 12 to 75 years with a biopsy proven diagnosis who present with primary steroid-resistant focal segmental glomerulosclerosis (FSGS) with proteinuria.

All eligible patients will be enrolled to receive R3R01 over a treatment period of 12 weeks with a primary efficacy outcome as the percentage change in proteinuria from baseline to the end of treatment (Day 84) in each cohort as a whole

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: June 2, 2025
• Est. primary completion date: March 10, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 12 Years and older

Eligibility

Inclusion Criteria:

All Patients:

1. Patient is able to communicate well with the investigator, understands and is willing to comply with all requirements of the study, and understands and signs the written informed consent form (ICF).

2. For children to be eligible, one or both parents/legal guardians must sign a parental permission form which provides information contained in the ICF. Children capable of assent must express their willingness to participate by signing an assent form.

3. If patient has received a COVID vaccination, the baseline visit must occur at least one week or more after the second/booster vaccination.

4. Patients who have had active symptoms of COVID within 3 months prior to screening and are now asymptomatic for the last 2 weeks but have tested COVID PCR positive. If a patient is asymptomatic at screening but is COVID positive, then rescreening can occur after a minimum of two weeks.

5. Both female patients, as well as, female partners of male patients who are of child-bearing potential must be willing to not become pregnant for the complete duration of the study (>180 days) (90 days after the last dose of study medication).

6. Males (including sterilized subjects) whose female partners have child-bearing potential, must agree to use male contraception (condoms) during the period from the time of signing the informed consent form (ICF) through 90 days after the last dose of study drug. They must agree to immediately inform the investigator if their partner becomes pregnant during the study.

Alport Syndrome Patients Inclusion Criteria (in addition):

7. Males and females with X-Linked AS and males and females with autosomal inherited AS.

1. For countries that are enrolling pediatric patients: patients from age 12 years and older.

2. For countries that are not enrolling pediatric patients: patients from age 18 years and older.

8. Confirmed diagnosis of AS by genetic testing and /or kidney biopsy. For patients enrolled in the US who meet all inclusion and exclusion criteria but have not had their diagnosis confirmed by genetic testing or kidney biopsy, the Sponsor will provide for patient's genetic testing.

9. UPCR =1.0 g/g.

10. eGFR = 45 mL/min/1.73m2 (using CKD-EPI equation for adults and Bedside Schwartz equation for children).

11. ACEi/ARB therapy at maximum tolerated dose stable for at least 4 weeks prior to screening. ACEi/ARB dose should remain stable over the course of the study.

Focal Segmental Glomerulosclerosis Patients Inclusion Criteria (in addition):

12. Male or female patients,

1. For countries that are enrolling pediatric patients: 12 to 75 years old at the time of signing the informed consent

2. For countries that are not enrolling pediatric patients: 18 to 75 years old at the time of signing the informed consent

13. Primary FSGS, (without any identifiable cause, and where the FSGS is confirmed by renal biopsy) or FSGS where there is documentation of a genetic mutation in a podocyte protein associated with FSGS.

14. Steroid-resistance defined as failure to achieve partial or complete remission, or experienced adverse events without acceptable clinical benefit after at least 8 weeks of adequate corticosteroid therapy for children and 12 weeks for adults.

15. UPCR between 3.5g/g and 12.0g/g.

16. eGFR > 45 mL/min/1.73m2 (using CKD-EPI equation for adults and Bedside Schwartz equation for children).

17. If taking concomitant ACEi and/or ARB treatment, it should remain at a stable dose for a minimum of 28 days prior to enrollment and during the course of the study.

Exclusion Criteria:

All Patients:

1. Uncontrolled diabetes mellitus as evidenced by an HbA1c = 11%. For Germany: HbA1c = 8.5%.

2. Uncontrolled hypertension

1. Adults: (SBP = 180mmHg and/or DBP = 100mmHg). For Germany: (SBP = 140mmHg and/or DBP = 100mmHg).

2. Children: = 95th percentile or = 130/80 mm Hg, whichever is lower

3. Moderate or severe hepatic impairment (Child-Pugh B or C), except if (a) decreased serum albumin is directly related to the renal disease (resulting in a Child Pugh score of 7), and (b) no other Child-Pugh Score parameters are increased and (c) patient has no liver pathology in medical history.

4. Presence of any active (i.e., with symptoms) and/or uncontrolled infection (including COVID).

5. Presence of Human immunodeficiency virus (HIV).

6. BMI > 40. Note - For Germany: BMI > 35 (Obesity Class II).

7. History of malignancy other than treated basal cell or squamous cell skin cancer within the past 5 years.

8. History of alcohol abuse in the last 5 years or currently drinks in excess of 21 and 14 units per week for males and females, respectively.

9. Received an investigational agent within 30 days or 5 half-lives prior to screening (whichever is longer).

10. History of non-compliance such that patient is unlikely to be compliant with study visits, procedures or drug administration.

11. Patient has had an organ transplant, is currently on an organ transplant waiting list or there is a reasonable possibility that the patient will have an organ transplant in the 6 months after screening.

12. Participation in an interventional trial within the previous 3 months prior to screening or concurrent participation in a research trial.

13. Patient is not suitable to participate in the study for any reason (including, but not limited to co-morbidities, history of non-compliance with study visits, procedures, or drug administration) in the opinion of the investigator.

14. Females of childbearing potential (those who are not surgically sterilized or post-menopausal for at least 1 year) are excluded from participation in the study unless they agree to use highly effective contraception.

15. Females that are lactating.

16. History of hypersensitivity to study drug and/or any of its excipients.

17. Patients with hereditary galactose intolerance, total lactase deficiency or glucose-galactose malabsorption.

18. Required concomitant use of bardoxolone, rituximab, cyclo-phosphamide, abatacept, or sparsentan

Alport Syndrome Patients Exclusion Criteria (in addition):

19. Kidney disease apart from AS, e.g. diabetic nephropathy or lupus nephritis.

20. Use of Bardoxolone or sparsentan treatment in the 30 days prior to screening. SGLT2 inhibitors are allowed if the patient is on a stable dose for at least 3 months prior to screening.

Focal Segmental Glomerulosclerosis Patients Exclusion Criteria (in addition):

21. Patient has collapsing variant of FSGS on renal biopsy.

22. Patient has FSGS secondary to another condition (e.g. obesity, cardiovascular, infectious, or autoimmune disorder).

23. Use of Rituximab, cyclophosphamide or abatacept treatment in the 120 days prior to screening. If taking other chronic immune-modulatory medications that are small molecules, the dosage must be stable for 4 weeks prior to screening.

24. If previous Rituximab treatment is greater than 120 days from screening, CD20 cell count should be within normal limits.

25. If previous other antibody treatment on a stable dose is greater than 120 days from screening, the investigator must deem administration of study drug to be safe.

26. Use of sparsentan in the 30 days prior to screening. SGLT2 inhibitors are allowed if the patient is on a stable dose for at least 3 months prior to screening.

Related Conditions & MeSH terms

• Alport Syndrome
• Focal Segmental Glomerulosclerosis
• Glomerulosclerosis, Focal Segmental
• Nephritis, Hereditary
• Syndrome

Intervention

Drug:
• R3R01
R3R01 administered orally for 12 weeks

Locations

Country	Name	City	State
Belgium	Investigative site	Bruxelles
Belgium	Investigative site	Liege
France	Investigative site	Grenoble
France	Investigative site	Paris
Germany	Investigative site	Berlin
Germany	Investigative site	Göttingen
Netherlands	Investigative site	Amsterdam
Netherlands	Investigative site	Nijmegen
United Kingdom	Investigative site	Leicester
United Kingdom	Investigative site	Manchester
United Kingdom	Investigative site	Nottingham
United States	Investigative site	Ann Arbor	Michigan
United States	Investigative site	Atlanta	Georgia
United States	Investigative site	Boston	Massachusetts
United States	Investigative Site	Cary	North Carolina
United States	Investigative site	Cleveland	Ohio
United States	Investigative site	Columbus	Ohio
United States	Investigative Site	Dallas	Texas
United States	Investigative site	Houston	Texas
United States	Investigative Site	Los Angeles	California
United States	Investigative site	Miami	Florida
United States	Investigative site	Minneapolis	Minnesota

Sponsors (1)

Lead Sponsor	Collaborator
River 3 Renal Corp.

Countries where clinical trial is conducted

United States,  Belgium,  France,  Germany,  Netherlands,  United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Incidence of adverse events (Safety and Tolerability)	Safety and tolerability as determined by the incidence of adverse events (AEs)	12 weeks
Primary	Assess change in urine creatinine protein ratio	Change from baseline in urine creatinine protein ratio for Cohort 1 (Alport Syndrome patient group) and Cohort 2(Focal Segmental Glomerulosclerosis patient group).	12 weeks
Secondary	Change in quality-of-life assessment from baseline to end of treatment and to the end of the follow-up period by cohort for adults	Change in quality of life as measured by the Short Form SF-36 for adults	24 weeks
Secondary	Change in quality-of-life assessment from baseline to end of treatment and to the end of the follow-up period by cohort for children	Change in quality of life as measured by the pediatric quality of life inventory (PedsQL) for children	24 weeks